INT215244

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.04

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1) embryo development (Racgap1) cytoplasm (Racgap1) pigmentation (Mlph)

Anatomy Link Frequency melanocytes 1 Racgap1 (Mus musculus) Mlph (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 6 82.48 imagery 4 5.00 Inflammatory mediators 2 5.00 cytokine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Anaphylaxis 10 92.56 Targeted Disruption 49 91.68 Hypersensitivity 6 11.80 Sprains And Strains 3 5.00 Syndrome 2 5.00 Disease 2 5.00 INFLAMMATION 2 5.00 Asthma 2 5.00 Exsanguination 1 5.00 Edema 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent studies on Rab27a in melanocytes have led to the proposal that the GTPase promotes the switch between MT-based motility to actin-based motility of melanosomes through the recruitment of Melanophilin and Myosin Va (17,18).

GTPase Binding (recruitment) of Melanophilin in melanocytes

1) Confidence 0.04 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.76 Pain Relevance 0.04

General Comments

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