INT215259

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.82
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Siglec1) cell adhesion (Siglec1) plasma membrane (Siglec1)
Siglec1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 66 99.32 Very High Very High Very High
agonist 9 97.84 Very High Very High Very High
Kinase C 13 93.20 High High
Inflammatory mediators 14 91.80 High High
Eae 1 82.60 Quite High
midbrain 8 63.24 Quite High
Hippocampus 3 51.44 Quite High
ischemia 2 43.28 Quite Low
cINOD 4 34.72 Quite Low
Central nervous system 6 18.12 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 85 99.32 Very High Very High Very High
Coronary Heart Disease 31 99.16 Very High Very High Very High
Drug Induced Neurotoxicity 61 98.60 Very High Very High Very High
Targeted Disruption 9 92.48 High High
Death 52 88.96 High High
Disease 120 88.08 High High
Diabetes Mellitus 19 86.56 High High
Hypertension 17 84.76 Quite High
Alzheimer's Dementia 6 79.52 Quite High
Apoptosis 19 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a protective effect of the Ser allele, with lower risk of diastolic dysfunction for each copy of the allele in men.
Negative_regulation (effect) of Ser allele associated with coronary heart disease
1) Confidence 0.14 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2637232 Disease Relevance 1.04 Pain Relevance 0
Our studies suggest that reduction in PHOX activity by SN at the site of inflammation diminishes host tissue damage, thereby underlying the neuroprotective effect of SN for both LPS- and MPP+-induced DA neurotoxicity.
Negative_regulation (effect) of SN associated with drug induced neurotoxicity and inflammation
2) Confidence 0.04 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.92 Pain Relevance 0.34
SN pretreatment suppresses LPS-induced pro-inflammatory factors production and gene expression
Negative_regulation (suppresses) of SN associated with inflammation
3) Confidence 0.04 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.47 Pain Relevance 0.13
whereas only negligible decrease in the amount of phospho-Ser9 GSK-3?
Negative_regulation (decrease) of Ser9
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.59 Pain Relevance 0
In this manner, Ser-9 phosphorylation/inactivation of GSK-3?
Negative_regulation (phosphorylation/inactivation) of Ser-9
5) Confidence 0.01 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.80 Pain Relevance 0.40

General Comments

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