INT21527

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 47
Total Number 51
Disease Relevance 11.20
Pain Relevance 34.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FosB) DNA binding (FosB)
Anatomy Link Frequency
PVN 5
brain 4
nucleus accumbens 4
striatum 3
medial 2
FosB (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 74 100.00 Very High Very High Very High
Opioid 27 100.00 Very High Very High Very High
Morphine 180 99.82 Very High Very High Very High
cocaine 46 99.82 Very High Very High Very High
Enkephalin 24 99.82 Very High Very High Very High
Ventral tegmentum 27 99.78 Very High Very High Very High
withdrawal 101 99.74 Very High Very High Very High
Nucleus accumbens 66 99.68 Very High Very High Very High
Sciatic nerve 5 99.54 Very High Very High Very High
psychological dependence 6 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 33 99.76 Very High Very High Very High
Weight Loss 8 99.66 Very High Very High Very High
Recurrence 12 99.64 Very High Very High Very High
Drug Dependence 42 99.38 Very High Very High Very High
Morphine Dependence 23 99.24 Very High Very High Very High
Syndrome 6 98.36 Very High Very High Very High
Dyskinesias 14 98.04 Very High Very High Very High
Injury 7 97.92 Very High Very High Very High
Disease 13 96.24 Very High Very High Very High
INFLAMMATION 7 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, sensitized D-rats showed a selective and significant increase in FosB expression in the nucleus accumbens (core and shell), basolateral amygdala and medial prefrontal cortex, brain areas that are functionally related to the rewarding neural circuit.
Gene_expression (expression) of FosB in medial associated with nucleus accumbens and amygdala
1) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17935891 Disease Relevance 0.06 Pain Relevance 0.66
These results demonstrate that a deficient nutritional status during the perinatal period results in adult subjects having neural alterations, leading to an increased responsiveness to morphine and/or enhanced reinforcement effects, which correlates with an overexpression of FosB in selective brain areas related to the rewarding network.
Gene_expression (overexpression) of FosB in brain associated with morphine
2) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17935891 Disease Relevance 0 Pain Relevance 0.59
We studied the effects of osmotic stimulation on the expression of FosB and c-Fos in the supraoptic nucleus (SON) and paraventricular nucleus (PVN).
Gene_expression (expression) of FosB in nucleus
3) Confidence 0.78 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899256 Disease Relevance 0 Pain Relevance 0.09
Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease.
Gene_expression (expression) of fosB associated with enkephalin, disease and dyskinesias
4) Confidence 0.76 Published 1999 Journal Neurobiol. Dis. Section Title Doc Link 10600402 Disease Relevance 0.36 Pain Relevance 0.15
Phosphorylation of ERK1/2, mitogen- and stress-activated protein kinase-1 (MSK-1), and the levels of FosB/DeltaFosB expression were examined immunohistochemically.
Gene_expression (expression) of FosB
5) Confidence 0.75 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
In intact rats, CREB antisense reduced both basal and cocaine-induced expression of c-Fos, FosB/DeltaFosB, and prodynorphin mRNA.
Gene_expression (expression) of FosB associated with cocaine
6) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11739600 Disease Relevance 0 Pain Relevance 0.34
Phosphorylation of ERK1/2, mitogen- and stress-activated protein kinase-1 (MSK-1), and the levels of FosB/DeltaFosB expression were examined immunohistochemically.
Gene_expression (expression) of FosB
7) Confidence 0.75 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
The suppressive effects of pentobarbital were not specific to c-Fos, such that pentobarbital also suppressed expression of ITFs FosB and Egr1 in the striatum of cocaine-treated rats.
Gene_expression (expression) of FosB in striatum associated with cocaine
8) Confidence 0.75 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0.06 Pain Relevance 0.67
Moreover, altered innate expression of FosB/DeltaFosB and pCREB in AA rats is likely to affect the sensitivity of these rats to abused drugs.
Gene_expression (expression) of FosB
9) Confidence 0.75 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 0.97
These findings suggest that enhanced sensitivity of AA rats to morphine is related to augmented morphine-induced expression of FosB/DeltaFosB and morphine-induced reduction of pCREB levels.
Gene_expression (expression) of FosB associated with morphine
10) Confidence 0.75 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.04
The present data provide the first demonstration that L-DOPA maintains high striatal levels of fosB and prodynorphin gene expression during a prolonged course of treatment, which simulates the clinical practice in Parkinson's disease more closely than the short-treatment paradigms studied thus far.
Gene_expression (expression) of fosB associated with disease
11) Confidence 0.73 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683909 Disease Relevance 0.37 Pain Relevance 0.07
This study investigates the effects of time postdenervation and L-dopa treatment duration on the striatal expression of opioid precursor mRNAs and FosB/DeltaFosB-related proteins.
Gene_expression (expression) of FosB associated with opioid
12) Confidence 0.73 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683909 Disease Relevance 0.33 Pain Relevance 0.14
Furthermore, agmatine inhibited the increased expression of FosB in the nucleus accumbens caused by chronic morphine.
Gene_expression (expression) of FosB in nucleus accumbens associated with nucleus accumbens and morphine
13) Confidence 0.71 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15899480 Disease Relevance 0.14 Pain Relevance 0.87
All these results suggest that agmatine could inhibit morphine-induced psychological dependence and relapses by affecting the expression of transcription factor FosB.
Gene_expression (expression) of FosB associated with psychological dependence, recurrence and morphine
14) Confidence 0.71 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15899480 Disease Relevance 0.33 Pain Relevance 0.82
To explore the transcriptional events that might be involved in this neurochemical regulation, we used immunohistochemistry and immunoblotting to examine the expression patterns of two bZip transcription factors, c-Fos and FosB, in the striatum of rats treated acutely and chronically with neuroleptic drugs of different classes.
Spec (examine) Gene_expression (expression) of FosB in striatum
15) Confidence 0.71 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8891947 Disease Relevance 0.09 Pain Relevance 0
Restraint stress also significantly increased (P < 0.05) expression of the immediate early genes c-Fos and FosB within the hypothalamic PVN to a similar extent in CCI and sham rats.
Gene_expression (expression) of FosB associated with stress and eae
16) Confidence 0.68 Published 2005 Journal Brain Res. Section Abstract Doc Link 15885220 Disease Relevance 1.66 Pain Relevance 1.01
In the lateral thalamus the repeated stimulation again failed to induce c-Fos, but the expressions of FosB, c-Jun and Krox-24 were increased, and that of JunD was again reduced.
Gene_expression (expressions) of FosB in lateral associated with thalamus
17) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.08 Pain Relevance 0.57
An intense input produced by electrical stimulation of all the C-fibers in one sciatic nerve also failed to induce expression of c-Fos, FosB, Krox-20 or Krox-24 in the medial or lateral areas.
Gene_expression (expression) of FosB in lateral areas associated with c fibre and sciatic nerve
18) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.78
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Gene_expression (expression) of FosB in lateral areas associated with c fibre
19) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.73
Either alone or in combination with L-DOPA, KW-6002 did not have any modulatory effect on prodynorphin mRNA expression or FosB/DeltaFosB-like immunoreactivity in the dopamine-denervated striatum.
Gene_expression (expression) of FosB in striatum associated with dopamine
20) Confidence 0.65 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12614340 Disease Relevance 0.41 Pain Relevance 0.26

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