INT215275

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.37
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Ros1) plasma membrane (Tlr4, Ros1) cell differentiation (Ros1)
cell proliferation (Ros1) intracellular (Tlr4) kinase activity (Ros1)
Anatomy Link Frequency
microglia 4
Tlr4 (Mus musculus)
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 93 97.24 Very High Very High Very High
Inflammatory mediators 21 94.80 High High
midbrain 12 65.76 Quite High
Inflammatory response 6 46.64 Quite Low
Potency 3 20.16 Low Low
Enkephalin 3 19.52 Low Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
narcan 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 66 98.12 Very High Very High Very High
INFLAMMATION 120 97.24 Very High Very High Very High
Toxicity 18 88.96 High High
Necrosis 6 76.28 Quite High
Cancer 6 75.92 Quite High
Death 18 65.12 Quite High
Disease 51 62.00 Quite High
Parkinson's Disease 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, only microglia express LPS receptors and are activated by LPS, and therefore no other cell is likely to produce ROS upon stimulation with LPS.
LPS Positive_regulation (stimulation) of Gene_expression (produce) of ROS in microglia
1) Confidence 0.01 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.32 Pain Relevance 0.10
We first tested the effect of SN on the LPS-induced ROS generation, including extracellular superoxide and intracellular ROS in microglia-enriched cultures.
LPS Positive_regulation (induced) of Gene_expression (generation) of ROS in microglia
2) Confidence 0.00 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.55 Pain Relevance 0.18
Furthermore, we demonstrated that SN reduced LPS-induced extracellular ROS production through the inhibition of the PHOX cytosolic subunit p47phoxtranslocation to the cell membrane.


LPS Positive_regulation (induced) of Gene_expression (production) of ROS
3) Confidence 0.00 Published 2007 Journal J Neuroinflammation Section Abstract Doc Link PMC2064906 Disease Relevance 0.50 Pain Relevance 0.10

General Comments

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