INT21528

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FosB) DNA binding (FosB)
Anatomy Link Frequency
spinal cord 1
SON 1
FosB (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 4 99.98 Very High Very High Very High
Spinal cord 2 98.56 Very High Very High Very High
Dorsal horn 2 93.04 High High
Hippocampus 4 77.40 Quite High
Dorsal horn neuron 1 76.84 Quite High
nociceptor 1 73.88 Quite High
lidocaine 1 71.08 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.
Negative_regulation (reducing) of FosB
1) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06
FosB staining was significantly reduced in both the SON and the PVN of rats that had ad libitum water compared to the two water-restricted groups.
Negative_regulation (reduced) of FosB in SON
2) Confidence 0.43 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899256 Disease Relevance 0 Pain Relevance 0.07
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, Fra-2, FosB, c-Jun, and JunB protein levels, which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin.
Negative_regulation (inhibited) of FosB
3) Confidence 0.33 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
Electrical stimulation in the medullary nucleus raphe magnus inhibits noxious heat-evoked fos protein-like immunoreactivity in the rat lumbar spinal cord.
Negative_regulation (inhibits) of fos protein-like in spinal cord associated with raphe magnus and spinal cord
4) Confidence 0.33 Published 1990 Journal Brain Res. Section Title Doc Link 2176120 Disease Relevance 0 Pain Relevance 0.48

General Comments

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