INT215281

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Mpz (Mus musculus)
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 7 91.96 High High
Inflammation 32 50.00 Quite Low
Eae 1 44.60 Quite Low
Dopamine 11 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 99.40 Very High Very High Very High
Parkinson's Disease 53 96.00 Very High Very High Very High
INFLAMMATION 41 91.56 High High
Drug Induced Neurotoxicity 24 87.12 High High
Apoptosis 7 79.96 Quite High
Disease 105 73.20 Quite High
Death 20 53.32 Quite High
Toxicity 13 18.92 Low Low
Teratocarcinoma 1 6.64 Low Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results demonstrated that SN can inhibit ROS production induced either directly by LPS stimulation or indirectly by MPP+-mediated reactive microgliosis, and lend further evidence to the idea that superoxide production, rather than TNF-?
MPP Positive_regulation (induced) of Gene_expression (production) of ROS
1) Confidence 0.01 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.40 Pain Relevance 0.05
Mitochondrial neurotoxins (MPP+, rotenone, 6-OHDA, etc) induce an increase production of ROS and oxidative stress (Sun et al., 2007).
MPP Positive_regulation (induce) of Gene_expression (production) of ROS associated with stress
2) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.60 Pain Relevance 0

General Comments

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