INT215283

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr4, Ncf1) cytoplasm (Tlr4, Ncf1) cell proliferation (Ncf1)
cytosol (Ncf1) signal transduction (Tlr4) Golgi apparatus (Ncf1)
Tlr4 (Mus musculus)
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 69 87.36 High High
cINOD 2 33.64 Quite Low
midbrain 4 21.28 Low Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 80 87.36 High High
Necrosis 6 82.52 Quite High
Cancer 8 82.16 Quite High
Parkinson's Disease 66 80.56 Quite High
Drug Induced Neurotoxicity 36 70.20 Quite High
Disease 41 64.92 Quite High
Death 14 57.04 Quite High
Neurodegenerative Disease 14 47.92 Quite Low
Toxicity 8 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis from this study revealed that FLZ inhibited LPS-induced p47phox translocation from cytosol to membrane.
LPS Positive_regulation (induced) of Localization (translocation) of p47phox
1) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.25 Pain Relevance 0
A critical role for PHOX in FLZ-elicited neuroprotection was further supported by the findings that 1) FLZ's protective effect was reduced in cultures from PHOX-/- mice, and 2) FLZ inhibited LPS-induced translocation of the cytosolic subunit of p47PHOX to the membrane and thus inhibited the activation of PHOX.
LPS Positive_regulation (induced) of Localization (translocation) of p47PHOX
2) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2413210 Disease Relevance 0.79 Pain Relevance 0.11
However, the addition of 10-14 M SN significantly prevented this LPS-induced p47phox translocation (Fig. 5, panel V and VI).
LPS Positive_regulation (induced) of Localization (translocation) of p47phox
3) Confidence 0.04 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0 Pain Relevance 0

General Comments

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