INT215290

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) extracellular region (Siglec1)
cell adhesion (Siglec1) nucleus (Decr1) plasma membrane (Siglec1)
Anatomy Link Frequency
microglia 1
Siglec1 (Mus musculus)
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 7 96.56 Very High Very High Very High
Inflammation 31 90.72 High High
opiate 1 86.52 High High
Dextromethorphan 1 64.88 Quite High
narcan 2 63.84 Quite High
Morphine 1 57.32 Quite High
Arthritis 1 35.48 Quite Low
rheumatoid arthritis 2 29.80 Quite Low
midbrain 4 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 22 97.00 Very High Very High Very High
INFLAMMATION 40 96.56 Very High Very High Very High
Disease 17 91.80 High High
Neurodegenerative Disease 4 89.84 High High
Hepatitis 1 38.48 Quite Low
Arthritis 1 35.48 Quite Low
Sprains And Strains 1 35.36 Quite Low
Rheumatoid Arthritis 2 29.80 Quite Low
Toxicity 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that SN is acting to inhibit NADPH oxidase (PHOX) activity, which then results in the inhibition of a wide array of pro-inflammatory mediators produced by activated microglia, suggests that SN may be a potential novel and safe therapeutic agent for the treatment of inflammatory-mediated neurodegenerative diseases.


SN Negative_regulation (inhibit) of NADPH in microglia associated with inflammatory mediators, inflammation and neurodegenerative disease
1) Confidence 0.00 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.68 Pain Relevance 0.41

General Comments

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