INT21532

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 47
Total Number 48
Disease Relevance 20.43
Pain Relevance 16.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 36
lymphocytes 8
spleen 3
thymus 3
plasma 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 276 100.00 Very High Very High Very High
Morphine 98 99.98 Very High Very High Very High
agonist 63 99.98 Very High Very High Very High
Opioid 9 99.68 Very High Very High Very High
tolerance 20 99.58 Very High Very High Very High
qutenza 10 99.42 Very High Very High Very High
Analgesic 13 99.16 Very High Very High Very High
opioid receptor 18 97.92 Very High Very High Very High
Multiple sclerosis 337 97.68 Very High Very High Very High
Bile 5 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 82 100.00 Very High Very High Very High
Influenza Virus Infection 96 99.86 Very High Very High Very High
Sepsis 58 99.58 Very High Very High Very High
Hepatitis 10 99.56 Very High Very High Very High
Targeted Disruption 71 99.50 Very High Very High Very High
Severe Combined Immunodeficiency 60 98.72 Very High Very High Very High
Immunization 72 98.24 Very High Very High Very High
Demyelinating Disease 56 97.68 Very High Very High Very High
Infection 99 97.32 Very High Very High Very High
Hepatotoxicity 3 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine tolerance and abstinence were associated with suppression of IL-2 production, which was completely blocked by naltrexone.
Negative_regulation (suppression) of Gene_expression (production) of IL-2 associated with tolerance and morphine
1) Confidence 0.59 Published 1995 Journal Brain Res. Section Abstract Doc Link 7496798 Disease Relevance 0.16 Pain Relevance 1.35
A centrally acting novel analgesic, PM, added to murine lymphocyte cultures abrogated the mitogenic response to Con A, as well as, interleukin 2 production, in a dose-dependent manner.
Negative_regulation (abrogated) of Gene_expression (production) of interleukin 2 in lymphocyte associated with analgesic
2) Confidence 0.57 Published 1990 Journal Int. J. Neurosci. Section Abstract Doc Link 2176182 Disease Relevance 0 Pain Relevance 0.67
Phenotypic responses such as, decreased thymic cellularity, compromised mitogenic response and inhibition of IL-2 synthesis that are evident at 48-72 h after LPS injection appear as early as 24 h in animals that receive morphine in addition to LPS.
Negative_regulation (inhibition) of Gene_expression (synthesis) of IL-2 associated with morphine
3) Confidence 0.48 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10229120 Disease Relevance 0.64 Pain Relevance 0.90
PG are known to inhibit T cell proliferation, at least in part by suppressing IL-2 production, but effects of PG on the production of other lymphokines have not been well studied.
Negative_regulation (suppressing) of Gene_expression (production) of IL-2 in T cell
4) Confidence 0.48 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0 Pain Relevance 0.03
One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in the production of IL-2.
Negative_regulation (decrease) of Gene_expression (production) of IL-2
5) Confidence 0.45 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9916880 Disease Relevance 0 Pain Relevance 0.09
In a dose-dependent fashion, dihydroetorphine (total doses at 444.5, 889 and 1778 microg/kg) lowered the increase of body weight, decreased the weight of the spleen and thymus, weakened the delayed-type hypersensitivity, reduced the generation of antibody-forming cells, inhibited splenic lymphocyte proliferation induced by concanavalin A and lipopolysaccharide, suppressed the production of interleukin-2 in the supernatant of splenocytes induced by concanavalin A, and depleted the ratio of CD4+ and CD8+ subpopulations.
Negative_regulation (suppressed) of in spleen Gene_expression (production) of interleukin-2 in thymus associated with body weight and hypersensitivity
6) Confidence 0.43 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082208 Disease Relevance 0.28 Pain Relevance 0.22
Morphine tolerance was associated with suppressed B-cell proliferation following in vitro stimulation, as well as interleukin-2 (IL-2) and interleukin-4 production by T-cells.
Negative_regulation (suppressed) of Gene_expression (production) of IL-2 in T-cells associated with tolerance and morphine
7) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032870 Disease Relevance 0.31 Pain Relevance 1.36
Morphine tolerance was associated with suppressed B-cell proliferation following in vitro stimulation, as well as interleukin-2 (IL-2) and interleukin-4 production by T-cells.
Negative_regulation (suppressed) of Gene_expression (production) of interleukin-2 in T-cells associated with tolerance and morphine
8) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032870 Disease Relevance 0.31 Pain Relevance 1.36
The reduced IL-2 concentration and reduced transcript levels correlated well with a decreased rate of synthesis of IL-2 mRNA as determined by nuclear runoff assays.
Negative_regulation (decreased) of Gene_expression (synthesis) of IL-2
9) Confidence 0.40 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
In addition, the production of IL-2 by the thymic T cells was also inhibited by the opioid treatment.
Negative_regulation (inhibited) of Gene_expression (production) of IL-2 in T cells associated with opioid
10) Confidence 0.39 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9143250 Disease Relevance 0 Pain Relevance 0.60
Phagocytosis-induced chemiluminescence of peritoneal macrophages was also enhanced whereas interleukin-1 production by these cells was depressed, but without concomitant modification in interleukin-2 production by T-cells.
Negative_regulation (depressed) of Gene_expression (production) of interleukin-2 in T-cells
11) Confidence 0.31 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784787 Disease Relevance 0.15 Pain Relevance 0.23
In addition, peripheral blood lymphocytes (PBMC) production of IL-2 was significantly decreased while transformin growth factor (TGF)?
Negative_regulation (decreased) of Gene_expression (production) of IL-2 in lymphocytes
12) Confidence 0.31 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.64 Pain Relevance 0.14
In another study, antigen- and mitogen-stimulated PBMC derived from patients with normal pregnancies demonstrated a decrease in the production of IL2 and IFN?
Negative_regulation (decrease) of Gene_expression (production) of IL2
13) Confidence 0.31 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.13 Pain Relevance 0.12
When spleen cells cultured without Con A, the production of IL-2 and IFN-?
Negative_regulation (cultured) of Gene_expression (production) of IL-2 in spleen
14) Confidence 0.29 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0 Pain Relevance 0
We found that although plasma CORT concentrations in CORT infusion (10 mg/kg/day) and morphine-pellet implantation (75 mg) mice were similar (400-450 ng/ml), chronic morphine treatment resulted in a significantly higher (two- to threefold) inhibition of thymic, splenic, and lymph node cellularity; inhibition of thymic-lymphocyte proliferation; inhibition of IL-2 synthesis; and activation of macrophage nitric oxide (NO) production when compared with CORT infusion.
Negative_regulation (inhibition) of Gene_expression (synthesis) of IL-2 in plasma associated with morphine
15) Confidence 0.28 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 11994502 Disease Relevance 0.08 Pain Relevance 0.77
Similarly, PG-specific IL-2 production (as measured by proliferation of IL-2-sensitive CTLL-2 cells) was not impaired by FTY720 treatment but was significantly reduced in the spleen cell cultures of SCID mice receiving T cell-depleted donor fractions (Figure 5d).
Negative_regulation (reduced) of Gene_expression (production) of IL-2 in T cell associated with severe combined immunodeficiency
16) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.23 Pain Relevance 0.04
Experiments undertaken to reveal the mechanism of action of opioid peptides suggest an overall enhancement of lymphokine production: (1) enhancement of IL-4 production occurred also in the presence of excess IL-2; and (2) neither IL-1 receptor-antagonizing protein nor anti-IL-6 were capable to abrogate the stimulatory effect on IL-2 and IL-4 production.
Negative_regulation (abrogate) of Gene_expression (production) of IL-2 associated with opioid
17) Confidence 0.25 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.76
Results show that morphine inhibits Con A-induced lymph node T-cell proliferation and IL-2 and IFN-gamma synthesis in a dose-dependent manner.
Negative_regulation (inhibits) of Gene_expression (synthesis) of IL-2 in T-cell associated with morphine
18) Confidence 0.25 Published 2001 Journal J. Leukoc. Biol. Section Abstract Doc Link 11590188 Disease Relevance 0.30 Pain Relevance 0.77
Twist1 reduces the functionality of Th1 cells by attenuating expression of IL-2, TNF-?
Negative_regulation (attenuating) of Gene_expression (expression) of IL-2 in Th1 cells
19) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 1.03 Pain Relevance 0.32
The capsaicin-induced enhancement of both IL-2 and IFN-gamma production was not reduced by oral administration of capsazepine (3 mg/kg/day), suggesting a TRPV1 receptor-independent mechanism.
Neg (not) Negative_regulation (reduced) of Gene_expression (production) of IL-2 associated with qutenza
20) Confidence 0.22 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306834 Disease Relevance 0 Pain Relevance 0.65

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