INT215322

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.06
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vdac1) mitochondrion (Vdac1) plasma membrane (Vdac1)
protein complex (Vdac1) transmembrane transport (Vdac1)
Vdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 12 84.04 Quite High
fluoxetine 8 80.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.38 Very High Very High Very High
Death 44 97.96 Very High Very High Very High
Apoptosis 60 97.72 Very High Very High Very High
Disease 20 84.52 Quite High
Stress 4 82.48 Quite High
Neurodegenerative Disease 20 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Dementia 4 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 4 5.00 Very Low Very Low Very Low
Tremor 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first confirmed that the transcriptional upregulation of Vdac1 was associated with a similar increase in the expression level of the protein.
Positive_regulation (upregulation) of Vdac1
1) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.27 Pain Relevance 0
VDAC1 protein levels were induced by 30 percent in 59Q TBP containing cells.
Positive_regulation (induced) of VDAC1
2) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.35 Pain Relevance 0
We examined the downstream cellular effects of the upregulation of Ubb and Vdac1 to correlate the changes in gene expression to neurodegeneration.
Spec (examined) Positive_regulation (upregulation) of Vdac1
3) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.17 Pain Relevance 0
Further investigations using chemical inhibitors or gene knock down strategies to negate the elevated Vdac1 transcript level can delineate the contribution of Vdac1 to the phenotypic effects of polyglutamine expansion in TATA binding protein.


Positive_regulation (elevated) of Vdac1 associated with targeted disruption
4) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.26 Pain Relevance 0.27

General Comments

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