INT215323

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Anatomy Link Frequency
proximal 2
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 9 5.00 Very Low Very Low Very Low
fluoxetine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 45 87.60 High High
Death 33 82.04 Quite High
Neurodegenerative Disease 15 71.36 Quite High
Disease 15 66.16 Quite High
Dementia 3 5.24 Low Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 3 5.00 Very Low Very Low Very Low
Tremor 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that many gene specific transcription factors exert their effects by directly or indirectly interacting with TBP and stabilizing TBP-TATA box interaction at the proximal promoter region [13], [14].
Positive_regulation (stabilizing) of TBP Binding (interaction) of in proximal
1) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
Chromatin Immunoprecipitation studies at a TATA containing and a TATA less promoter from the differentially expressed genes suggested that TBP occupancy was elevated in vivo.
Positive_regulation (elevated) of TBP Binding (occupancy) of
2) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.50 Pain Relevance 0
We find that TBP occupancy at the promoter of upregulated genes was elevated irrespective of the presence of the TATA box.
Positive_regulation (elevated) of TBP Binding (occupancy) of
3) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.42 Pain Relevance 0

General Comments

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