INT215327

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vdac1) mitochondrion (Vdac1) plasma membrane (Vdac1)
protein complex (Vdac1) transmembrane transport (Vdac1)
Anatomy Link Frequency
neuronal 12
Vdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 38 5.00 Very Low Very Low Very Low
fluoxetine 23 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 55 99.92 Very High Very High Very High
Apoptosis 166 99.48 Very High Very High Very High
Targeted Disruption 13 99.34 Very High Very High Very High
Death 122 99.32 Very High Very High Very High
Disease 56 94.72 High High
Stroke 11 66.76 Quite High
Stress 19 30.76 Quite Low
Pressure And Volume Under Development 27 5.00 Very Low Very Low Very Low
Dementia 11 5.00 Very Low Very Low Very Low
Tremor 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, consistent with our hypothesis of maxi-anion channelmediated ATP release, ATP release was diminished in VDAC-1 knock-out mice and augmented in cells overexpressing pl-VDAC-1 [275].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VDAC-1 associated with targeted disruption
1) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.10 Pain Relevance 0
Our results suggest a previously unknown mechanistic basis linking transcriptional dysregulation to cell death in neurodegeneration through TBP mediated alteration of Vdac1 expression.
Positive_regulation (mediated) of Gene_expression (expression) of Vdac1 associated with death
2) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.57 Pain Relevance 0
Further, we studied cytochrome c release from the mitochondria following increase in VDAC1 expression.
Positive_regulation (increase) of Gene_expression (expression) of VDAC1
3) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.46 Pain Relevance 0
Vdac1 overexpression, independently implicated in triggering cell death was one of the effects of polyglutamine expansion in TBP, identified in our study.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Vdac1 associated with death
4) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.72 Pain Relevance 0
The cells expressing 59Q TBP showed a gradual increase in cytochrome c release resulting in substantially higher Cyt c levels at time points beyond 36 hours compared to cells which express the vector alone (Fig. 7B), in agreement with increased expression of VDAC1.
Positive_regulation (increased) of Gene_expression (expression) of VDAC1
5) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.57 Pain Relevance 0
We confirmed a similar effect of VDAC1 in neuronal cells by cloning and overexpressing mouse VDAC1 (Fig. 8A–E).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VDAC1 in neuronal
6) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.53 Pain Relevance 0
In this study we show that alleles of TBP harbouring abnormally expanded polyQ tracts not only form intranuclear aggregates in cultured mouse neuronal cells, but also result in overexpression of the voltage dependent anion channel, Vdac1 at both the RNA and protein level.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Vdac1 in neuronal
7) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.57 Pain Relevance 0
Previous studies have shown that overexpression of VDAC1 can lead to apoptosis in non-neuronal cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of VDAC1 in neuronal associated with apoptosis
8) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.65 Pain Relevance 0
In this study we show that alleles of TBP harbouring abnormally expanded polyQ tracts not only form intranuclear aggregates in cultured mouse neuronal cells, but also result in overexpression of the voltage dependent anion channel, Vdac1 at both the RNA and protein level.
Positive_regulation (result) of Gene_expression (overexpression) of Vdac1 in neuronal
9) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.57 Pain Relevance 0
In our studies, VDAC1 overexpression lead to elevated cytochrome c release and apoptotic cell death in mouse neuronal cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of VDAC1 in neuronal associated with apoptosis and death
10) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.59 Pain Relevance 0
We independently confirmed that Vdac1 overexpression in mouse neuronal cells results in higher cytochrome c release and apoptosis, as has been reported for non-neuronal cells previously [23].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Vdac1 in neuronal associated with apoptosis
11) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.40 Pain Relevance 0
Similar method was followed for Cyt c release assay in case of mVdac1GFP transfected cells.
Positive_regulation (transfected) of Gene_expression (transfected) of mVdac1GFP
12) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.07 Pain Relevance 0

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