INT21533

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Context Info
Confidence 0.25
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 4.78
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1f5) extracellular region (Il1f5) molecular_function (Il1f5)
biological_process (Il1f5)
Anatomy Link Frequency
nerves 1
brain 1
peritoneal macrophages 1
Il1f5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
Inflammatory marker 1 100.00 Very High Very High Very High
Root ganglion neuron 1 99.88 Very High Very High Very High
Inflammation 22 99.80 Very High Very High Very High
dexamethasone 4 99.80 Very High Very High Very High
ischemia 7 99.36 Very High Very High Very High
allodynia 2 98.20 Very High Very High Very High
Neuropathic pain 3 96.90 Very High Very High Very High
Peripheral nerve injury 1 96.32 Very High Very High Very High
narcan 2 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 44 100.00 Very High Very High Very High
INFLAMMATION 33 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Cv General 4 Under Development 4 99.72 Very High Very High Very High
Ganglion Cysts 1 99.72 Very High Very High Very High
Pre-term Labor 9 99.48 Very High Very High Very High
Osteogenic Sarcomas 1 98.64 Very High Very High Very High
Brain Hemorrhage 5 98.60 Very High Very High Very High
Adhesions 5 98.56 Very High Very High Very High
Neuropathic Pain 7 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-ulcer actions of endotoxin were not observed in endotoxin-insensitive animals (C3H/HeJ mice), thereby suggesting that endogenous cytokines such as interleukin-1 may mediate these protective actions.
Spec (may) Positive_regulation (mediate) of interleukin-1 associated with ulcers and cytokine
1) Confidence 0.25 Published 1993 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8280150 Disease Relevance 0.28 Pain Relevance 0.14
Serum interleukin-6 rose rapidly, reaching a peak at hour 2 (P < .001) and then declining through hour 6, but interleukin-1 and tumor necrosis factor, were elevated in only a few animals undergoing laparotomy.
Positive_regulation (elevated) of interleukin-1
2) Confidence 0.22 Published 1996 Journal Reg Anesth Section Body Doc Link 8896011 Disease Relevance 0 Pain Relevance 0
Peripheral nerve injury may lead to neuropathic pain, which is often associated with mechanical and thermal allodynia, ectopic discharge of from injured nerves and from the dorsal root ganglion neurons, and elevated levels of proinflammatory cytokines, particularly interleukin-1 (IL-1).
Positive_regulation (elevated) of interleukin-1 in nerves associated with ganglion cysts, nervous system injury, allodynia, root ganglion neuron, neuropathic pain, cytokine and peripheral nerve injury
3) Confidence 0.18 Published 2006 Journal Pain Section Abstract Doc Link 16426759 Disease Relevance 1.27 Pain Relevance 0.70
Simultaneous presence of interleukin 1 (IL-1) and interleukin 2 (IL-2) into the cultures counteracted, in a dose-dependent manner, as naloxone does, the immunosuppressive action of PM as well as of Pethidine, a known opioid agonist.
Positive_regulation (presence) of interleukin 1 associated with mu agonist, algil and narcan
4) Confidence 0.16 Published 1990 Journal Int. J. Neurosci. Section Abstract Doc Link 2176182 Disease Relevance 0 Pain Relevance 0.72
This opposite modulatory role of interleukin-1 and dexamethasone on intercellular adhesion molecule-1 expression was also, for the first time, observed in vivo using mouse peritoneal macrophages: a four-fold increase in intercellular adhesion molecule-1 expression was measured after local administration of the cytokine (5 micrograms/kg) and this effect was greatly inhibited (> 70%) by co-injection with 1 microgram dexamethasone.
Positive_regulation (role) of interleukin-1 in peritoneal macrophages associated with dexamethasone, adhesions and cytokine
5) Confidence 0.10 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.43 Pain Relevance 0.28
Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice

Interleukin-18 (IL-18) is a proinflammatory cytokine of the interleukin-1 family which is upregulated after cerebral ischemia.

Positive_regulation (upregulated) of interleukin-1 in brain associated with brain hemorrhage, cv general 4 under development, ischemia and cytokine
6) Confidence 0.06 Published 2010 Journal Exp Transl Stroke Med Section Title Doc Link PMC2820471 Disease Relevance 0.56 Pain Relevance 0.20
In both term and preterm labor, there is evidence of an increase in inflammatory markers tumor necrosis factor (TNF) -alpha, interleukin-1 (IL-1) and interleukin-6 (IL-6), and down-regulation of the anti-inflammatory interleukin-10 (IL-10).78,79 Inflammatory cytokines may alter enzyme expression, increasing prostaglandin production prior to the onset of labor.78,79 These maternal inflammatory mediators may then interact at the feto-placental unit, precipitating preterm birth.80 In particular, inflammatory cytokines interleukin-1 and TNF-alpha act to increase prostaglandin production, while both IL-10 and progesterone have a negative effect on prostaglandin production.63
Positive_regulation (increase) of interleukin-1 associated with premature birth, cytokine, inflammatory mediators, necrosis, inflammation, inflammatory marker, cancer and pre-term labor
7) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971700 Disease Relevance 1.10 Pain Relevance 0.48
It has recently been demonstrated that the inflammatory mediator interleukin-1ß is increased in the area of an induced tibial osteosarcoma and within the inflamed paws of injected mice.44 Similar results have also been published by Zhang and colleagues.45

Conclusion

Positive_regulation (increased) of interleukin-1 associated with inflammation and osteogenic sarcomas
8) Confidence 0.00 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004636 Disease Relevance 1.14 Pain Relevance 0.25

General Comments

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