INT215337

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 9 5.00 Very Low Very Low Very Low
fluoxetine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 33 84.60 Quite High
Apoptosis 45 75.72 Quite High
Disease 15 20.04 Low Low
Neurodegenerative Disease 15 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Dementia 3 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 3 5.00 Very Low Very Low Very Low
Tremor 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We substantiated the model by cytological observation of large intranuclear aggregates only in cells transfected with TBP variants carrying expanded polyQ (Fig.
Positive_regulation (transfected) of Gene_expression (transfected) of TBP
1) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.45 Pain Relevance 0
Any indirect effect arising from differential transfection or expression of the transfected TBP in 16Q and 59Q constructs was ruled out by real-time PCR analysis and northern analysis of GFP transcript expressed in fusion with the transfected TBP alleles (Fig. 2B, Fig. 3A–C).
Positive_regulation (transfected) of Gene_expression (expression) of TBP
2) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
The situation in 59Q TBP transfected cells is likely to be totally different due to the apparent aggregation of a significant fraction of the transfected protein (Fig.
Positive_regulation (transfected) of Gene_expression (transfected) of TBP
3) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0

General Comments

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