INT21534

Context Info Confidence 0.00 First Reported 1990 Last Reported 1990 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.84

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Oprd1 (Rattus norvegicus) Il1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 2 100.00 antagonist 2 100.00 opioid receptor 1 100.00 MU agonist 2 98.96 algil 1 98.00 Endogenous opioid 2 97.12 narcan 2 95.40 Analgesic 1 83.68

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results show that IL-1 and IL-2 together exhibit classical agonist-antagonist opioid receptor interactions and support the hypothesis that these lymphokines might play a role as endogenous opioid receptor antagonists against endogenous opioid agonists.

opioid receptor Binding (interactions) of IL-1 associated with antagonist, endogenous opioid, agonist and opioid receptor

1) Confidence 0.00 Published 1990 Journal Int. J. Neurosci. Section Abstract Doc Link 2176182 Disease Relevance 0 Pain Relevance 0.84

General Comments

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