INT215340

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.12
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neurons 1
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 25 93.00 High High
Inflammation 46 92.64 High High
Central nervous system 28 89.32 High High
depression 4 86.56 High High
Inflammatory response 17 81.20 Quite High
cINOD 15 62.40 Quite High
Inflammatory mediators 18 39.52 Quite Low
Clonidine 14 18.00 Low Low
Glutamate 48 5.00 Very Low Very Low Very Low
cerebral cortex 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 410 100.00 Very High Very High Very High
Death 72 98.60 Very High Very High Very High
Neurological Disease 2 98.24 Very High Very High Very High
Apoptosis 51 97.60 Very High Very High Very High
INFLAMMATION 85 92.64 High High
Chorea 2 92.16 High High
Disease Progression 10 91.80 High High
Cognitive Disorder 11 88.48 High High
Depression 4 86.56 High High
Toxicity 70 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ku70-shRNA knockdown and EGFP-Htt expression vectors
Localization (vectors) of EGFP-Htt
1) Confidence 0.61 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.13 Pain Relevance 0
Higher magnification and confocal microscopic analyses revealed colocalization of Ku70 and mutant Htt both in inclusion bodies and the nucleoplasm (Fig. 4 C).
Localization (colocalization) of mutant Htt
2) Confidence 0.57 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Mutant Htt and Ku70 were also colocalized in striatal neurons of R6/2 mice (Fig. 4 B).
Localization (colocalized) of Mutant Htt in neurons
3) Confidence 0.57 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Mutant htt is found in glial nuclei where it can act to alter gene expression, probably because of its aberrant interactions with transcription factors that are made possible by glutamine expansion-related conformational changes in the htt protein [119].
Localization (found) of htt
4) Confidence 0.47 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.25 Pain Relevance 0.47
We have previously shown that mutant huntingtin is cleared by (macro)autophagy, a finding that has been subsequently replicated by others (11,12).
Localization (cleared) of mutant huntingtin
5) Confidence 0.33 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.71 Pain Relevance 0
Proteolysis of mutant huntingtin releases a persistent N-terminal fragment comprising the first 100–150 residues with the expanded polyglutamine sequence.
Localization (releases) of mutant huntingtin
6) Confidence 0.31 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.97 Pain Relevance 0
HD (Huntington’s disease) is a progressive, debilitating, and fatal neurological disorder.
Localization (disease) of Huntington associated with neurological disease and disease
7) Confidence 0.29 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.73 Pain Relevance 0.04
HD (Huntington’s disease) is a progressive, debilitating, and fatal neurological disorder.
Localization (disease) of HD associated with neurological disease and disease
8) Confidence 0.29 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.73 Pain Relevance 0.04
Further, Ruan et al., observed that mutant huntingtin was unable to release cytochrome c in the cytosol and striatal cells undergo non-apoptotic death [21].
Neg (unable) Localization (release) of huntingtin associated with apoptosis and death
9) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.33 Pain Relevance 0
One week after electroporation, the formation of inclusions was observed in all fibres electroporated with Htt41Q and Htt74Q.
Localization (electroporated) of Htt41Q
10) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.14 Pain Relevance 0
One week after electroporation, the formation of inclusions was observed in all fibres electroporated with Htt41Q and Htt74Q.
Localization (electroporated) of Htt74Q
11) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.14 Pain Relevance 0

General Comments

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