INT215341

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Htt, Sp1) nucleus (Htt, Sp1) transcription factor binding (Htt, Sp1)
Golgi apparatus (Htt) endoplasmic reticulum (Htt) intracellular (Sp1)
Anatomy Link Frequency
brain 1
Htt (Mus musculus)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 5 72.88 Quite High
Dementia 1 61.44 Quite High
Tremor 1 60.92 Quite High
Spinocerebellar Ataxia Type 2 1 42.44 Quite Low
Neurodegenerative Disease 5 26.28 Quite Low
Death 11 6.04 Low Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strongest evidence for transcriptional dysregulation comes from the observed interaction between the glutamine rich regions of Sp1 with Huntingtin protein harbouring polyglutamine expansion in brain tissue from Huntington patients [11].
Huntingtin Binding (interaction) of Sp1 in brain
1) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.25 Pain Relevance 0

General Comments

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