INT215353

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 9.71
Pain Relevance 9.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tcf21)
Anatomy Link Frequency
sensory neurons 1
sciatic nerve 1
nerve 1
dorsal horn 1
Tcf21 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 279 100.00 Very High Very High Very High
Spinal nerve ligature 456 99.98 Very High Very High Very High
Sciatic nerve 75 99.78 Very High Very High Very High
Demyelination 235 99.08 Very High Very High Very High
imagery 36 98.90 Very High Very High Very High
chemokine 524 98.32 Very High Very High Very High
Dorsal horn 88 98.26 Very High Very High Very High
ketamine 192 97.88 Very High Very High Very High
Neuropathic pain 324 96.72 Very High Very High Very High
antagonist 100 91.80 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 611 100.00 Very High Very High Very High
Necrosis 53 99.96 Very High Very High Very High
Injury 175 99.48 Very High Very High Very High
Demyelinating Disease 240 99.08 Very High Very High Very High
Nervous System Injury 244 97.84 Very High Very High Very High
Wound Healing 21 96.96 Very High Very High Very High
Toxicity 10 94.96 High High
Nephrotoxicity 42 94.16 High High
Abdominal Pain 3 89.64 High High
Stress 3 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in situ hybridization we examined lumbar DRG associated with the injured sciatic nerve for SDF-1 expression at POD14.
Gene_expression (expression) of POD14 in sciatic nerve associated with sciatic nerve
1) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.09
The FDG uptake of kidneys with acute tubular necrosis (ATN: POD1: 0.25±0.02%, POD2: 0.21±0.04%, POD4: 0.31±0.02%, n?
Gene_expression (0.25) of POD1 associated with necrosis
2) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669171 Disease Relevance 0.39 Pain Relevance 0
The FDG uptake of kidneys with acute tubular necrosis (ATN: POD1: 0.25±0.02%, POD2: 0.21±0.04%, POD4: 0.31±0.02%, n?
Gene_expression (0.25) of POD2 associated with necrosis
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669171 Disease Relevance 0.39 Pain Relevance 0
Many sensory neurons were positive for CXCR3 mRNA in tissues taken from both naïve (data not shown) and sham-treated rodents at POD14 (Fig. 5A).
Gene_expression (positive) of POD14 in sensory neurons
4) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.56 Pain Relevance 0.32
DRGs taken from injured animals on POD35 exhibited CXCR4 mRNA staining that was similar to that seen in naïve and vehicle-treated animals (data not shown).
Gene_expression (exhibited) of POD35
5) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.44 Pain Relevance 0.46
The pattern of neuronal expression of CXCR3 mRNA at POD14 following focal nerve demyelination did not change relative to naïve or sham-treated tissue, but the nerve injury did increase the intensity of CXCR3 mRNA expression in the DRG ipsilateral to the injury (Fig. 5C), as well as in the contralateral DRG (data not shown).
Gene_expression (expression) of POD14 in nerve associated with demyelination, nervous system injury and injury
6) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.57 Pain Relevance 0.26
L4L5 DRGs removed from naïve (data not shown) and vehicle-treated rats at POD7 did not express CCR2 mRNA (Fig. 2A) or CCR2 immunoreactivity (Fig. 2B).
Neg (not) Gene_expression (express) of POD7
7) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.81 Pain Relevance 0.59
A magnetic resonance imaging (MRI) scan showed a collection of fluid occupying the POD and subsequently a subcutaneous collection was found during an ultrasound scan.
Gene_expression (found) of POD associated with imagery
8) Confidence 0.20 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2435545 Disease Relevance 1.02 Pain Relevance 0.35
Treatment with L-AA significantly reversed the ipsilateral allodynia on POD 3 (PWT?
Gene_expression (allodynia) of POD 3 associated with allodynia
9) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.70 Pain Relevance 1.12
L-AA treatment rendered inhibitory effect on the enhanced Fos expression on POD 1 and 3.
Gene_expression (expression) of POD 1
10) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0 Pain Relevance 0.37
Treatment with ASO significantly reversed the ipsilateral allodynia on POD 1 (PWT?
Gene_expression (allodynia) of POD 1 associated with allodynia
11) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.69 Pain Relevance 1.25
But a very important finding is that: Fos up-regulation can not be detected on POD 7 but c-fos ASO still influences allodynia at this time point.
Neg (not) Gene_expression (detected) of POD 7 associated with allodynia
12) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.81 Pain Relevance 0.99
Our changing course study of GFAP expression in the ipsilateral superficial dorsal horn of Saline and L-AA groups indicated that there were no obvious differences at 2 h and POD 1 when no obvious astrocytic activation could be detected (Fig. 5D).
Neg (no) Gene_expression (detected) of POD 1 in dorsal horn associated with dorsal horn
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.14 Pain Relevance 0.84
The L-AA treatment and POD had significant effect on the SNL-induced ipsilateral allodynia [Fig. 1B; two way ANOVA (between subjects factors: Group and Day): Group: F (1,216)?
Gene_expression (treatment) of POD associated with allodynia and spinal nerve ligature
14) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.66 Pain Relevance 1.19
g/kg) and LAA (50 nmol) simultaneously to SNL rats on POD 7 intrathecally.
Gene_expression (rats) of POD associated with spinal nerve ligature
15) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.62 Pain Relevance 1.56
Then on POD 7, behavioral tests were performed 30 min before, and 10 min, 30 min, 60 min, 2 h, 6 h, 12 h, 24 h, 48 h, and 72 h after drug administration, respectively.
Gene_expression (on) of POD
16) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.11 Pain Relevance 0.09
Differences in the recovery of wound-breaking properties were decreasing on POD 14 and appeared to become less marked with time, consistent with normal acute wound healing (Fig. 6).
Gene_expression (decreasing) of POD 14 associated with wound healing and injury
17) Confidence 0.06 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC2064968 Disease Relevance 1.14 Pain Relevance 0

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