INT215360

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.63
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPE1) protein folding (HSPE1) mitochondrion (HSPE1)
response to stress (HSPE1) cytoplasm (HSPE1)
Anatomy Link Frequency
plasma 2
plaque 1
mouth 1
HSPE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 24 99.92 Very High Very High Very High
Arthritis 8 96.00 Very High Very High Very High
Inflammation 248 87.84 High High
Inflammatory stimuli 8 73.84 Quite High
cytokine 16 62.12 Quite High
analgesia 8 51.48 Quite High
Inflammatory response 40 31.08 Quite Low
Inflammatory marker 8 16.60 Low Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 8 100.00 Very High Very High Very High
Rheumatoid Arthritis 24 99.92 Very High Very High Very High
Periodontitis 152 99.08 Very High Very High Very High
Periodontal Disease 64 98.00 Very High Very High Very High
Arthritis 16 96.00 Very High Very High Very High
Periodontal Pocket 24 95.92 Very High Very High Very High
Dental Plaque 40 95.00 High High
Stress 32 92.44 High High
INFLAMMATION 304 87.84 High High
Nicotine Addiction 32 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSP10, or early pregnancy factor (EPF) inhibits the development of autoimmune disease in rats [34] and has recently been administered to a small number of patients with rheumatoid arthritis with therapeutic benefit [35].
HSP10 Binding (administered) of associated with autoimmune disease and rheumatoid arthritis
1) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.86 Pain Relevance 0.36
Within 24hrs of therapy the IPT patients exhibited substantial increases in their plasma concentrations of HSP10 (difference between changes from baseline between groups 1633 ng/ml , 95%CI 181–3086, P?
HSP10 Binding (concentrations) of in plasma
2) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.27 Pain Relevance 0
Bound HSP10 was detected by incubation with goat polyclonal antibody to HSP10 (clone C-20, Santa Cruz Biotechnology) at 1?
HSP10 Binding (Bound) of
3) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0 Pain Relevance 0
HSP10, or early pregnancy factor (EPF) inhibits the development of autoimmune disease in rats [34] and has recently been administered to a small number of patients with rheumatoid arthritis with therapeutic benefit [35].
EPF Binding (administered) of associated with autoimmune disease and rheumatoid arthritis
4) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.79 Pain Relevance 0.36
Bound HSP10 was detected by incubation with goat polyclonal antibody to HSP10 (clone C-20, Santa Cruz Biotechnology) at 1?
HSP10 Binding (incubation) of
5) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0 Pain Relevance 0
Of interest was the finding in the periodontitis patients that there was a consistent inverse association between HSP10 plasma concentrations and clinical parameters of periodontal disease severity, such as the number of periodontal pockets or dental plaque scores.
HSP10 Binding (association) of in plaque associated with periodontitis, dental plaque, periodontal pocket and periodontal disease
6) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.94 Pain Relevance 0.19
We also observed a consistent inverse association between plasma concentrations of HSP10and clinical periodontal parameters (averaged whole mouth probing depths, r?
HSP10and Binding (association) of in mouth
7) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.49 Pain Relevance 0
Of the circulating molecular chaperones being measured, we only observed an association between periodontal therapy and the concentrations of plasma HSP10 (Figure 3).
HSP10 Binding (association) of in plasma
8) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.27 Pain Relevance 0

General Comments

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