INT215361

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPE1) protein folding (HSPE1) mitochondrion (HSPE1)
response to stress (HSPE1) cytoplasm (HSPE1)
Anatomy Link Frequency
blood 1
plasma 1
HSPE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 93 99.38 Very High Very High Very High
Inflammatory marker 3 91.84 High High
Inflammatory response 15 71.36 Quite High
cytokine 6 46.52 Quite Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 99.84 Very High Very High Very High
INFLAMMATION 114 99.38 Very High Very High Very High
Periodontitis 57 98.48 Very High Very High Very High
Periodontal Disease 24 98.40 Very High Very High Very High
Stress 12 55.84 Quite High
Shock 6 55.36 Quite High
Hemorrhage 9 28.88 Quite Low
Periodontal Pocket 9 24.40 Low Low
Dental Plaque 15 20.40 Low Low
Nicotine Addiction 12 16.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, almost nothing is known about circulating levels of other molecular chaperones such as BiP or HSP10 in human blood or how such levels relate to disease status.
Regulation (relate) of HSP10 in blood associated with disease
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.73 Pain Relevance 0.17
Two site ELISAs were used to measure the concentrations of HSP10, HSP60 and BiP in plasma samples.
Regulation (concentrations) of HSP10 in plasma
2) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.16 Pain Relevance 0.08
We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP.


Spec (determine) Regulation (effects) of HSP10 associated with periodontitis and inflammation
3) Confidence 0.26 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.51 Pain Relevance 0.09

General Comments

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