INT215362

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPE1) protein folding (HSPE1) mitochondrion (HSPE1)
response to stress (HSPE1) cytoplasm (HSPE1)
HSPE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 62 99.66 Very High Very High Very High
cytokine 4 95.40 Very High Very High Very High
analgesia 2 84.76 Quite High
Inflammatory stimuli 2 67.04 Quite High
Arthritis 2 51.44 Quite High
rheumatoid arthritis 6 44.48 Quite Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.66 Very High Very High Very High
Acute-phase Reaction 2 90.36 High High
Dental Plaque 10 83.52 Quite High
Periodontitis 38 76.56 Quite High
Periodontal Pocket 6 58.00 Quite High
Periodontal Disease 16 55.92 Quite High
Arthritis 4 51.44 Quite High
Stress 8 44.60 Quite Low
Rheumatoid Arthritis 6 44.48 Quite Low
Autoimmune Disease 2 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spite of the elevation in the levels of these pro-inflammatory indicators, the levels of HSP10 in the circulation were increased significantly at one day following therapy and were still elevated after 6 months, when the acute phase protein and endothelial dysfunction had returned to baseline, showing that levels of this protein are environmentally controlled.
Positive_regulation (elevated) of Gene_expression (levels) of HSP10 associated with inflammation
1) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.94 Pain Relevance 0.37
In spite of the elevation in the levels of these pro-inflammatory indicators, the levels of HSP10 in the circulation were increased significantly at one day following therapy and were still elevated after 6 months, when the acute phase protein and endothelial dysfunction had returned to baseline, showing that levels of this protein are environmentally controlled.
Positive_regulation (increased) of Gene_expression (levels) of HSP10 associated with inflammation
2) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.88 Pain Relevance 0.34

General Comments

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