INT215363

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.74
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1)
extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)
Anatomy Link Frequency
plasma 1
HSPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 165 99.38 Very High Very High Very High
Crohn's disease 49 99.18 Very High Very High Very High
Inflammatory marker 4 91.84 High High
cytokine 21 82.48 Quite High
analgesia 4 71.84 Quite High
Inflammatory response 21 71.36 Quite High
Arthritis 4 70.40 Quite High
rheumatoid arthritis 12 63.44 Quite High
Inflammatory stimuli 4 54.12 Quite High
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 191 99.38 Very High Very High Very High
Disease 105 99.18 Very High Very High Very High
Periodontitis 76 98.48 Very High Very High Very High
Periodontal Disease 32 82.40 Quite High
Acute-phase Reaction 4 77.44 Quite High
Dental Plaque 20 70.60 Quite High
Arthritis 8 70.40 Quite High
Rheumatoid Arthritis 12 63.44 Quite High
Autoimmune Disease 9 56.32 Quite High
Shock 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, there were no significant changes in the levels of HSP60 or BiP after therapy.
Neg (no) Regulation (changes) of HSP60
1) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.82 Pain Relevance 0.37
ratio between normal control and CD groups were statistically significantly different for HSP60-derived peptide stimulation with P1, P7 and P8.
Regulation (different) of HSP60 associated with crohn's disease
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.64 Pain Relevance 0.29
Treatment had no influence of HSP60 levels.
Neg (no) Regulation (influence) of HSP60
3) Confidence 0.23 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.61 Pain Relevance 0.16
We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP.


Spec (determine) Regulation (effects) of HSP60 associated with periodontitis and inflammation
4) Confidence 0.23 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.51 Pain Relevance 0.09
Two site ELISAs were used to measure the concentrations of HSP10, HSP60 and BiP in plasma samples.
Regulation (concentrations) of HSP60 in plasma
5) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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