INT215366

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.39
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPE1) protein folding (HSPE1) mitochondrion (HSPE1)
response to stress (HSPE1) cytoplasm (HSPE1)
Anatomy Link Frequency
plasma 2
head 2
liver 1
HSPE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 385 99.66 Very High Very High Very High
cytokine 24 95.40 Very High Very High Very High
analgesia 12 84.76 Quite High
Inflammatory stimuli 12 67.04 Quite High
Inflammatory mediators 12 65.52 Quite High
rheumatoid arthritis 36 63.52 Quite High
Arthritis 12 51.96 Quite High
Inflammatory response 60 36.88 Quite Low
Inflammatory marker 12 16.36 Low Low
Pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 48 99.78 Very High Very High Very High
INFLAMMATION 462 99.66 Very High Very High Very High
Periodontal Disease 96 99.32 Very High Very High Very High
Periodontitis 228 98.26 Very High Very High Very High
Disease 73 94.88 High High
Cardiovascular Disease 24 92.16 High High
Acute-phase Reaction 12 90.36 High High
Shock 24 89.20 High High
Dental Plaque 60 83.52 Quite High
Disorder Of Lipid Metabolism 12 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bound HSP10 was detected by incubation with goat polyclonal antibody to HSP10 (clone C-20, Santa Cruz Biotechnology) at 1?
Gene_expression (detected) of HSP10
1) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0 Pain Relevance 0
If HSP10 synthesis did decrease in periodontal disease a corresponding decrease in HSP60 concentrations would be expected, and was not observed in this study.
Gene_expression (synthesis) of HSP10 associated with periodontal disease
2) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.62 Pain Relevance 0.16
Decreased synthesis of HSP10 is unlikely as the genes encoding both HSP10 and HSP60 are organized in a head-to-head fashion with a shared bidirectional promoter [35].
Gene_expression (synthesis) of HSP10 in head
3) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.56 Pain Relevance 0.13
After adjustment for age, gender, ethnicity and cigarette smoking, the odds for high HSP10 (?
Gene_expression (for) of HSP10 associated with nicotine addiction
4) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.71 Pain Relevance 0.03
Most attention has focused on circulating levels of the co-chaperone of HSP10, a protein termed HSP60.
Gene_expression (chaperone) of HSP10
5) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.44 Pain Relevance 0.03
Moreover, unlike conventional acute phase proteins that are largely synthesized in the liver, HSP10 and HSP60 are found in every cell as nuclear encoded genes which function within the mitochondria.
Gene_expression (found) of HSP10 in liver
6) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.56 Pain Relevance 0.15
EPF and hCG have been detected in a limited number of copper IUD users (<1%).13,18–20 It is important to note that many of these studies used earlier generation copper IUDs with a copper content lower than that in the Copper T-380A.
Gene_expression (detected) of EPF
7) Confidence 0.58 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971735 Disease Relevance 0.23 Pain Relevance 0.03
In spite of the elevation in the levels of these pro-inflammatory indicators, the levels of HSP10 in the circulation were increased significantly at one day following therapy and were still elevated after 6 months, when the acute phase protein and endothelial dysfunction had returned to baseline, showing that levels of this protein are environmentally controlled.
Gene_expression (levels) of HSP10 associated with inflammation
8) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.87 Pain Relevance 0.34
Plasma levels of HSP10, HSP60 and BiP were measured by immunoassay and related to other plasma measures of inflammation.
Gene_expression (levels) of HSP10 in plasma associated with inflammation
9) Confidence 0.57 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.55 Pain Relevance 0.12
Periodontal patients had significantly less circulating levels of HSP10 or BiP compared with the controls.
Gene_expression (levels) of HSP10
10) Confidence 0.57 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.62 Pain Relevance 0.15
Plasma from individuals with the highest plasma levels of HSP10 were assayed at least twice in separate assays.


Gene_expression (levels) of HSP10 in plasma
11) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.09 Pain Relevance 0
Decreased synthesis of HSP10 is unlikely as the genes encoding both HSP10 and HSP60 are organized in a head-to-head fashion with a shared bidirectional promoter [35].
Gene_expression (synthesis) of HSP10 in head
12) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.62 Pain Relevance 0.16
We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP.


Spec (determine) Gene_expression (levels) of HSP10 associated with periodontitis and inflammation
13) Confidence 0.57 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.51 Pain Relevance 0.09

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