INT215378

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Context Info
Confidence 0.86
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.12
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 228 99.84 Very High Very High Very High
rheumatoid arthritis 7 97.36 Very High Very High Very High
Multiple sclerosis 66 96.16 Very High Very High Very High
COX-2 inhibitor 1 95.96 Very High Very High Very High
Inflammation 126 95.84 Very High Very High Very High
chemokine 22 93.68 High High
Paracetamol 3 92.12 High High
corticosteroid 2 91.76 High High
cytokine 42 89.92 High High
dexamethasone 32 89.76 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 68 99.78 Very High Very High Very High
Rheumatoid Arthritis 7 97.36 Very High Very High Very High
Increased Venous Pressure Under Development 6 97.28 Very High Very High Very High
Demyelinating Disease 88 96.16 Very High Very High Very High
INFLAMMATION 140 95.84 Very High Very High Very High
Inflammatory Bowel Disease 4 94.32 High High
Cancer 93 93.36 High High
Necrosis 9 93.12 High High
Asthma 53 92.88 High High
Hypoxia 1 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
our ability to correctly understand the metabolic roles of PPARs, but also for
Protein_catabolism (roles) of PPAR
1) Confidence 0.86 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.21 Pain Relevance 0
These studies have provided the proof of principle for the use of PPAR-?
Protein_catabolism (use) of PPAR
2) Confidence 0.72 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 1.51 Pain Relevance 0.59
These data further suggests that Wy14,643 may have a PPAR?
Protein_catabolism (have) of PPAR
3) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.28 Pain Relevance 0.22
agonist in the prevention of steatohepatitis in Ppar?
Protein_catabolism (steatohepatitis) of Ppar associated with agonist
4) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.37 Pain Relevance 0.24
of PPAR is altered and stabilized, and the PPAR-RXR heterodimer then recruits
Protein_catabolism (stabilized) of PPAR
5) Confidence 0.62 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
serine phosphorylation promotes the degradation of PPAR?
Protein_catabolism (degradation) of PPAR
6) Confidence 0.62 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.05
in liver has also been observed in certain gene knockout mouse models of lipid metabolism, implying the existence of enzymes that either generate (synthesize) or degrade endogenous PPAR?
Protein_catabolism (degrade) of PPAR in liver associated with targeted disruption
7) Confidence 0.57 Published 2010 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2858266 Disease Relevance 0.54 Pain Relevance 0.16
Furthermore, the effect of arachidonic acid was mimicked by administration of either 15d-PGJ2 or the PPAR-?
Protein_catabolism (administration) of PPAR
8) Confidence 0.56 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.12 Pain Relevance 0.12
signaling then degrades to form 15d-PGJ2, which activates PPAR?
Protein_catabolism (degrades) of PPAR
9) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.56 Pain Relevance 0.18
Our study is the first to demonstrate PPAR-?
Protein_catabolism (demonstrate) of PPAR
10) Confidence 0.53 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.80 Pain Relevance 0.40
However, in conditional knockout mice, the degree of PPAR?
Protein_catabolism (degree) of PPAR associated with targeted disruption
11) Confidence 0.47 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.48 Pain Relevance 0.16
unlike most nuclear receptors, degradation of PPAR?
Protein_catabolism (degradation) of PPAR
12) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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