INT215379

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.04
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 296 99.98 Very High Very High Very High
Glutamate 22 99.98 Very High Very High Very High
ischemia 40 95.80 Very High Very High Very High
Inflammatory mediators 8 88.52 High High
Inflammation 275 87.84 High High
cva 5 76.48 Quite High
antagonist 29 76.40 Quite High
aspirin 12 75.92 Quite High
Inflammatory stimuli 5 73.04 Quite High
Kinase C 4 69.68 Quite High
Disease Link Frequency Relevance Heat
Death 48 100.00 Very High Very High Very High
Cancer 304 99.60 Very High Very High Very High
Breast Cancer 31 99.32 Very High Very High Very High
Adhesions 34 98.08 Very High Very High Very High
Sprains And Strains 23 97.76 Very High Very High Very High
Stress 35 97.04 Very High Very High Very High
Prostate Cancer 5 96.00 Very High Very High Very High
Apoptosis 70 95.80 Very High Very High Very High
Brain Hemorrhage 5 95.80 Very High Very High Very High
Colon Cancer 54 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression due to the stabilization of the binding of PPAR?
Positive_regulation (stabilization) of PPAR Binding (binding) of
1) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.06
activation by microgram-order perfluorooctanoate, a ligand of PPAR?
Positive_regulation (activation) of PPAR Binding (ligand) of
2) Confidence 0.49 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.41 Pain Relevance 0.07
is independent of the promoter context but appears to depend on a physical interaction between PPAR?
Spec (appears) Positive_regulation (depend) of PPAR Binding (interaction) of
3) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.92 Pain Relevance 0.34
assays are based on direct interaction between PPAR and their specific ligands,
Positive_regulation (based) of PPAR Binding (interaction) of
4) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.16 Pain Relevance 0.30
An important activity of PPAR?
Positive_regulation (important) of PPAR Binding (activity) of
5) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.95 Pain Relevance 0.12
In the case of activation assay for PPAR?
Positive_regulation (activation) of PPAR Binding (assay) of
6) Confidence 0.46 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.12 Pain Relevance 0
known to induce many genes that are not indicative of PPAR?
Positive_regulation (induce) of PPAR Binding (indicative) of
7) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 1.03 Pain Relevance 0.09
support a role for PPAR?
Positive_regulation (support) of PPAR Binding (role) of
8) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 1.14 Pain Relevance 0.04
induces the SUMOylation of a fraction of some PPAR-?
Positive_regulation (induces) of PPAR Binding (fraction) of
9) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.19 Pain Relevance 0.13
require high-affinity binding of PPAR ligand to engage transcription [7].
Positive_regulation (require) of PPAR Binding (binding) of
10) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.37 Pain Relevance 0.14
When their respective ligands bind to PPAR and RXR,
Positive_regulation (When) of PPAR Binding (bind) of
11) Confidence 0.40 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.08 Pain Relevance 0.08
from glutamate-induced death demonstrating a direct action of PPAR?
Positive_regulation (induced) of PPAR Binding (action) of associated with glutamate and death
12) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288640 Disease Relevance 0.97 Pain Relevance 0.53
These coactivator proteins enhance transcription through various means including histone acetyltransferase activity, methyltransferase activity or mediating the interaction of the activated PPAR-RXR heterodimer with the basal transcription machinery of the cell [29–35].
Positive_regulation (mediating) of PPAR-RXR Binding (interaction) of
13) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2946606 Disease Relevance 0.18 Pain Relevance 0.03
agonists increase expression and DNA binding of PPAR-?
Positive_regulation (increase) of PPAR Binding (binding) of associated with agonist
14) Confidence 0.29 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.59 Pain Relevance 0.43
Expression of PIMT enhances the activity of PPAR?
Positive_regulation (enhances) of PPAR Binding (activity) of
15) Confidence 0.27 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
increases the expression, S84 phosphorylation, and activity of PPAR?
Positive_regulation (increases) of PPAR Binding (activity) of
16) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.94 Pain Relevance 0

General Comments

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