INT215380

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.51
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36)
cell adhesion (Cd36) Golgi apparatus (Cd36) plasma membrane (Cd36)
Anatomy Link Frequency
macrophages 6
neuronal 2
monocytes 2
neutrophils 2
Cd36 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 61 100.00 Very High Very High Very High
tolerance 41 98.48 Very High Very High Very High
Inflammation 422 98.08 Very High Very High Very High
Hippocampus 45 93.20 High High
agonist 91 82.88 Quite High
Multiple sclerosis 127 72.08 Quite High
cannabis 2 70.48 Quite High
Delta-9-tetrahydrocannabinol 2 66.96 Quite High
Inflammatory mediators 5 66.88 Quite High
depression 10 53.24 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 178 99.76 Very High Very High Very High
Death 51 99.14 Very High Very High Very High
Impaired Glucose Tolerance 33 98.80 Very High Very High Very High
Necrosis 31 98.76 Very High Very High Very High
Cancer 157 98.40 Very High Very High Very High
INFLAMMATION 456 98.08 Very High Very High Very High
Apoptosis 34 97.04 Very High Very High Very High
Increased Venous Pressure Under Development 10 95.32 Very High Very High Very High
Infection 244 93.76 High High
Injury 38 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that enhanced expression of CD36 and CPT1 perhaps contributes to the maintenance of normal glucose tolerance despite the absence of GPR40 under basal conditions, but that the absence of such an increase under HFD results in an inability of the mice to sustain normal GSIS.
Positive_regulation (enhanced) of Gene_expression (expression) of CD36 associated with tolerance and impaired glucose tolerance
1) Confidence 0.47 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.68 Pain Relevance 0.05
Although expression of neither CD36 nor CPT-1 was significantly affected by HFD in WT animals, in KO islets the increase in CD36 and CPT1 gene expression was markedly reduced by HFD.
Positive_regulation (increase) of Gene_expression (expression) of CD36 associated with targeted disruption
2) Confidence 0.47 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.66 Pain Relevance 0.04
Further, the increased expression of PD-1 ligand and CD36 raise the provocative questions about whether T. gondii shares mechanisms to down-modulate critical protective immune functions that also allow latency in infections with certain viruses or cause pro-inflammation contributing to neurodegeneration.
Positive_regulation (increased) of Gene_expression (expression) of CD36 associated with inflammation and infection
3) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.27 Pain Relevance 0.12
GPR40 KO mice on regular diet displayed an approximate five and sevenfold increase in islet CD36 and CPT-1 mRNA expression, respectively, compared with WT islets (Table 1), suggesting an attempt to compensate for the absence of GPR40 by enhancing fatty acid transport and intracellular metabolism.
Positive_regulation (increase) of Gene_expression (expression) of CD36 associated with targeted disruption
4) Confidence 0.34 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.52 Pain Relevance 0.03
This suggests that enhanced expression of CD36 and CPT1 perhaps contributes to the maintenance of normal glucose tolerance despite the absence of GPR40 under basal conditions, but that the absence of such an increase under HFD results in an inability of the mice to sustain normal GSIS.
Positive_regulation (contributes) of Gene_expression (expression) of CD36 associated with tolerance and impaired glucose tolerance
5) Confidence 0.32 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.69 Pain Relevance 0.05
In addition, there was increased expression of the Suppression of Cytokine Signaling (SOCS), CD36, and PD-1L genes and others including C1q.
Positive_regulation (increased) of Gene_expression (expression) of CD36 associated with cytokine
6) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.46 Pain Relevance 0.13
Microarrays provide insight into the molecular pathogenesis of the processes in the outbred mice reflecting inflammation, attenuation of this inflammation by counter regulatory processes, neuronal cell death and potential remodeling of synapses with increased expression of C1q, as well as CD36, immunoglobin genes, GFAP, and PD-1L in these transcriptomes.
Positive_regulation (increased) of Gene_expression (expression) of CD36 in neuronal associated with inflammation and death
7) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.13 Pain Relevance 0.29
ligands together have an additive effect on upregulation of CD36 production by potentiating the transcription of the CD36 gene in monocytes [226].
Positive_regulation (upregulation) of Gene_expression (production) of CD36 in monocytes
8) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.90 Pain Relevance 0.04
leading to increased expression of ABCA1 and CD36 in macrophages [28, 29].
Positive_regulation (increased) of Gene_expression (expression) of CD36 in macrophages
9) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.51 Pain Relevance 0.16
leading to increased expression of ABCA1 and CD36 in macrophages [28, 29].
Positive_regulation (leading) of Gene_expression (expression) of CD36 in macrophages
10) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.52 Pain Relevance 0.16
-induced increase in CD36 expression might accelerate lipid uptake in macrophages, subsequent activation of LXR?
Positive_regulation (increase) of Gene_expression (expression) of CD36 in macrophages
11) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.42 Pain Relevance 0.03
while simultaneously upregulating expression of CD36, a scavenger receptor that mediates phagocytosis of (among other things) apoptotic neutrophils [67]; phagocytosis of apoptotic neutrophils is typical during the resolution of inflammation.
Positive_regulation (upregulating) of Gene_expression (expression) of CD36 in neutrophils associated with inflammation and apoptosis
12) Confidence 0.09 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.75 Pain Relevance 0.19

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