INT215415

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1, MAPK8) cytoplasm (MAP3K1, MAPK8) nucleoplasm (MAPK8)
mitochondrion (MAPK8) nucleus (MAPK8) cytoskeleton (MAP3K1)
MAP3K1 (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 99.04 Very High Very High Very High
Stress 20 94.08 High High
Death 2 83.52 Quite High
Cancer 14 78.08 Quite High
Shock 12 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Pox Virus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested this hypothesis on MEKK1, since the SAPK/JNK pathway that is regulated by MEKK1 has been implicated in apoptosis and cell growth, processes that are also impacted by ITCs.
MEKK1 Regulation (regulated) of JNK associated with apoptosis
1) Confidence 0.62 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.47 Pain Relevance 0
We therefore tested the effects of nutritional ITCs on MEKK1, an upstream regulator of the SAPK/JNK signal transduction pathway.


MEKK1 Regulation (regulator) of JNK
2) Confidence 0.12 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0.17 Pain Relevance 0

General Comments

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