INT215418

Context Info Confidence 0.03 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0.08

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1) cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)

MAP2K1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 81.68 cytokine 1 80.64 Immobilon 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Stress 10 99.12 Shock 6 83.44 INFLAMMATION 1 81.68 Apoptosis 16 75.12 Cancer 7 5.00 Pain 1 5.00 Death 1 5.00 Pox Virus Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It directly phosphorylates and activates the SEK1 protein kinase, leading to activation of the stress activated protein kinase/jun N terminal kinase (SAPK/JNK) [1,2].

Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of SEK1 protein kinase associated with stress

1) Confidence 0.03 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.51 Pain Relevance 0.08

General Comments

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