INT215423

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1) cytoskeleton (MAP3K1) cytoplasm (MAP3K1)
MAP3K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 30 86.24 High High
Cancer 21 63.00 Quite High
Apoptosis 48 32.88 Quite Low
Shock 18 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Pox Virus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This demonstrates both that C1238 is required for modification of MEKK1 by Bio-ITC, and also that none of the other cysteines of MEKK1 can be stably modified by Bio-ITC.
Localization (required) of MEKK1
1) Confidence 0.68 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0 Pain Relevance 0
MEKK1 is covalently labeled by a new ITC probe: Biotin-ITC
Localization (labeled) of MEKK1
2) Confidence 0.68 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0 Pain Relevance 0
To determine whether inhibition of MEKK1 is due to direct modification of MEKK1 and not an effect on another member of the signaling pathway, we examined the sensitivity of purified MEKK1 to PEITC treatment in vitro.
Localization (modification) of MEKK1
3) Confidence 0.68 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.22 Pain Relevance 0

General Comments

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