INT215427

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 61.92 Quite High
Dorsal horn 1 20.08 Low Low
Spinal cord 39 5.00 Very Low Very Low Very Low
Nerve growth factor 11 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 100.00 Very High Very High Very High
Shock 6 99.00 Very High Very High Very High
Injury 33 75.52 Quite High
INFLAMMATION 5 61.92 Quite High
Apoptosis 20 45.44 Quite Low
Spinal Cord Injury 53 22.56 Low Low
Cancer 8 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Contusions 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
hMNP transplantation altered intracellular signaling pathways (Fig. 5e,f). 1 day following transplantation, we observed an 86.3% decrease in phosphorylation of stress-associated protein kinase (SAPK) in hMNP-transplanted animals (p<0.001).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of stress-associated protein kinase associated with stress
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.29 Pain Relevance 0.03
As expected, we observed that PEITC specifically inhibited the activating phosphorylation of SAPK induced by hyperosmotic shock using sorbitol (Figure 8, Panel A), consistent with the inhibition seen by in vitro kinase assay.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of SAPK associated with shock
2) Confidence 0.09 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.52 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox