INT215428

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1) cytoskeleton (MAP3K1) cytoplasm (MAP3K1)
MAP3K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 53.24 Quite High
Cancer 14 30.00 Quite Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Shock 12 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Pox Virus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus PEITC inhibition of MEKK1 requires both access to the ATP-binding pocket of MEKK1 and the cysteine at position 1238.


MEKK1 Binding (binding) of
1) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0 Pain Relevance 0
Since C1238 is within the ATP binding domain of MEKK1, we suspected that occupancy of the ATP-binding pocket of MEKK1 might render MEKK1 resistant to modification by PEITC.
MEKK1 Binding (binding) of
2) Confidence 0.32 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.05 Pain Relevance 0

General Comments

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