INT21543

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Context Info
Confidence 0.09
First Reported 1990
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1, Cish) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Cish (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
MU agonist 1 99.88 Very High Very High Very High
Potency 5 94.64 High High
Enkephalin 1 87.60 High High
antagonist 5 75.00 Quite High
Opioid 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Catalepsy 1 80.44 Quite High
Catatonia 1 66.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potent opioid agonist, (+)-cis-3-methylfentanyl binds pseudoirreversibly to the opioid receptor complex in vitro and in vivo: evidence for a novel mechanism of action.
opioid receptor Binding (binds) of cis-3-methylfentanyl associated with mu agonist and opioid receptor
1) Confidence 0.09 Published 1990 Journal Life Sci. Section Title Doc Link 2176265 Disease Relevance 0.15 Pain Relevance 0.42
Neither the N-substituted cis-cinnamyl nor the cis-phenylcyclopropylmethyl compounds 10 and 11, respectively, showed high affinity for the opioid receptor.
opioid receptor Binding (affinity) of cis-cinnamyl associated with opioid receptor
2) Confidence 0.00 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9599247 Disease Relevance 0 Pain Relevance 0.36

General Comments

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