INT215454

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 8.07
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

amd (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 4 100.00 Very High Very High Very High
alcohol 3 100.00 Very High Very High Very High
Inflammation 76 92.96 High High
cva 38 59.08 Quite High
depression 20 55.12 Quite High
imagery 14 5.00 Very Low Very Low Very Low
eye pain 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 704 100.00 Very High Very High Very High
Nicotine Addiction 39 100.00 Very High Very High Very High
INFLAMMATION 85 92.96 High High
Genetic Predisposition To Disease 4 91.12 High High
Apoptosis 21 85.68 High High
Injury 25 85.12 High High
Hyperopia 3 82.16 Quite High
Increased Venous Pressure Under Development 10 81.72 Quite High
Hypoxia 3 78.08 Quite High
Blindness 7 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The value of this model is that each of these factors can be studied to determine whether cigarette smoking has a synergistic effect on important endpoints of AMD.


Spec (whether) Regulation (effect) of AMD associated with nicotine addiction and age-related macular degeneration
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.39 Pain Relevance 0.05
Preclinical evidence suggested that ranibizumab had potential to be an effective treatment for neovascular AMD.
Regulation (effective) of AMD associated with age-related macular degeneration
2) Confidence 0.36 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.60 Pain Relevance 0
A more recent study suggests that the SNP in the LOC387715 (ARMS2) gene has direct effects on AMD risk presumably by affecting protein function, whereas the SNP in HTRA1 may be through an indirect pathway (Kanda et al. 2007).
Regulation (effects) of AMD associated with age-related macular degeneration
3) Confidence 0.36 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.25 Pain Relevance 0
Collectively, these data provide a strong rationale for targeting VEGF in the treatment of wet AMD.
Regulation (targeting) of AMD associated with age-related macular degeneration
4) Confidence 0.13 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426796 Disease Relevance 1.07 Pain Relevance 0.03
However, we should also pay attention to the fact that other risk factors for AMD such as alcohol consumption and smoking nicotine can directly affect the level of complement activation and CRegs.
Regulation (affect) of AMD associated with nicotine addiction, nicotine, age-related macular degeneration and alcohol
5) Confidence 0.06 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 1.24 Pain Relevance 0.18
A protective effect on AMD was demonstrated in participants using a diet rich of antioxidants and zinc intake in our study population.
Regulation (effect) of AMD associated with age-related macular degeneration
6) Confidence 0.03 Published 2007 Journal Eur J Epidemiol Section Body Doc Link PMC2071967 Disease Relevance 1.87 Pain Relevance 0.03
In view of the encouraging results, further randomized controlled studies may be justified to determine the role of this combined therapy for neovascular AMD.



Spec (determine) Regulation (role) of AMD associated with age-related macular degeneration
7) Confidence 0.02 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698683 Disease Relevance 0.65 Pain Relevance 0

General Comments

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