INT21546

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 4.21
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
plasma 2
skeletal muscle 1
vesicle 1
platelet 1
adipocytes 1
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 63 99.84 Very High Very High Very High
anesthesia 5 99.84 Very High Very High Very High
Neurotransmitter 3 99.84 Very High Very High Very High
agonist 7 96.16 Very High Very High Very High
Pain threshold 1 95.76 Very High Very High Very High
long-term potentiation 1 93.76 High High
addiction 4 90.72 High High
Inflammation 42 75.00 Quite High
Hippocampus 12 71.76 Quite High
Kinase C 17 62.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 159 99.28 Very High Very High Very High
Disorder Of Lipid Metabolism 64 99.10 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 14 98.82 Very High Very High Very High
Pain 22 95.76 Very High Very High Very High
Age-related Macular Degeneration 64 95.64 Very High Very High Very High
Stress 93 95.60 Very High Very High Very High
Aging 7 88.72 High High
Anaphylaxis 1 75.24 Quite High
INFLAMMATION 48 75.00 Quite High
Atherosclerosis 21 73.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, apoA-I also stimulates the secretion of apolipoprotein E (apoE); this action is probably partially dependent on ABCA1 [4].
Spec (partially) Regulation (dependent) of ABCA1 associated with disorder of lipid metabolism
1) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.77 Pain Relevance 0
Moreover, this release is not linked to the transcriptional regulation of the ABCA1 gene, because apoA-I induced efflux does not lead to an increase in ABCA1 gene expression (figure 1).
Regulation (regulation) of ABCA1 gene
2) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.37 Pain Relevance 0
We demonstrate that apoA-I induces a strong increase in cholesterol release and apoE secretion from adipocytes, whereas it has no transcriptional effect on ABCA1 or apoE genes.
Neg (no) Regulation (effect) of ABCA1 in adipocytes associated with obesity
3) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2917427 Disease Relevance 0.88 Pain Relevance 0
Complement components are found alongside drusen and the RPE-choroid interface [110], and abnormal macular dysregulation of the complement cascade in RPE and Bruch's membrane appears to cause unrestrained complement activation and drusen formation [112].
Spec (appears) Regulation (dysregulation) of membrane in choroid associated with ocular toxicity (including many sub-types)
4) Confidence 0.14 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.14 Pain Relevance 0
Normal physiological functioning includes the transmission of axonal information, regulation of membrane-bound enzymes, control of ionic channels and various receptors.
Regulation (regulation) of membrane-bound
5) Confidence 0.06 Published 2002 Journal Neurobiol. Aging Section Abstract Doc Link 12392789 Disease Relevance 0.40 Pain Relevance 0.14
CONCLUSIONS: These results identify key membrane transporters as modulators of skeletal muscle statin exposure and toxicity.


Regulation (modulators) of membrane in skeletal muscle
6) Confidence 0.03 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.06 Pain Relevance 0
The aim of the present work was to investigate if this lack of effect of thiopental on the Na+/K+ ATPase activity might be due to its specificity of action on definite membrane proteins or if the binding sites of the anesthetic to this enzyme might be masked within the membrane.
Regulation (specificity) of membrane
7) Confidence 0.02 Published 1990 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2176486 Disease Relevance 0 Pain Relevance 0.13
Previously it was demonstrated that thiopental in vivo anesthesia didn't affect the Na+/K(+)-ATPase activity of syncythiotrophoblast plasma membrane, while affecting other enzymatic activity.
Regulation (affect) of membrane in plasma associated with anesthesia
8) Confidence 0.02 Published 1990 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2176486 Disease Relevance 0 Pain Relevance 0.14
The hypothesis was raised that the modulation of platelet membrane fluidity by EDTA might underlie platelet spontaneous activation in the presence of EDTA.
Regulation (modulation) of membrane in platelet
9) Confidence 0.01 Published 1998 Journal Platelets Section Abstract Doc Link 16793756 Disease Relevance 0 Pain Relevance 0
As previously indicated, detergents have been established to alter membrane properties.
Regulation (alter) of membrane
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0
Because the tested lipids comprise the main constituents of biological membranes, we speculate that a similar effect also occurs in cell membranes and that this NSAID effect alters the membrane micro-environment with concomitant changes on protein localization and function.
Regulation (alters) of membrane associated with cinod
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.18
This marked Indo-induced change in phase behavior potentially alters membrane protein functions, which contribute to the wide variety of biological activities of Indo and other NSAIDs.



Regulation (alters) of membrane associated with cinod
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2809093 Disease Relevance 0.07 Pain Relevance 0.13
The nine membrane-bound isoforms of the enzyme adenylate cyclase (EC 4.6.1.1) are highly regulated by neurotransmitters and drugs acting through G protein-coupled receptors to modulate intracellular cAMP levels.
Regulation (regulated) of membrane-bound associated with neurotransmitter
13) Confidence 0.01 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065693 Disease Relevance 0 Pain Relevance 0.05
Nevertheless, trans-plasma membrane electron transport (plasma membrane redox control) probably ranks alongside the Na+/H+ antiport system (pH control) and glucose transport in facilitating cellular responses to physiological stimuli.
Regulation (control) of membrane in plasma
14) Confidence 0.01 Published 2000 Journal Antioxid. Redox Signal. Section Abstract Doc Link 11229528 Disease Relevance 0 Pain Relevance 0
Glucocorticoids activate steroid receptor mediated transcriptional regulation and membrane receptors, inducing changes which serve to mobilize energy and inhibit other potentially costly reactions to stress.
Regulation (regulation) of membrane associated with stress
15) Confidence 0.00 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.25 Pain Relevance 0.12
In parallel, we also evaluated whether the effects of quercetin on basophil membrane markers were reproduced using a classical assay of histamine release.
Spec (whether) Regulation (effects) of membrane in basophil
16) Confidence 0.00 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0.20 Pain Relevance 0.14
The human genome siRNA subset library targeting the endocytic and membrane-trafficking genes (Dharmacon, RTF H-005500) was used in this study.
Regulation (targeting) of membrane
17) Confidence 0.00 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.07 Pain Relevance 0
Exocytosis of the molecules from the vesicular compartment requires the fusion of the vesicle membrane with the plasma membrane, a process presumably regulated by protein phosphorylation and dephosphorylation (16).
Regulation (regulated) of membrane in vesicle
18) Confidence 0.00 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0

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