INT215469

Context Info Confidence 0.43 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 7.14 Pain Relevance 0.70

cell proliferation (TNFSF13B) signal transduction (TNFSF13B) extracellular space (TNFSF13B) extracellular region (TNFSF13B) plasma membrane (TNFSF13B)

Anatomy Link Frequency blood 2 B cells 2 plasma 1 saliva 1 TNFSF13B (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 27 96.28 Inflammation 21 94.72 cytokine 54 90.24 chemokine 59 70.60 rheumatoid arthritis 26 60.88 cerebral cortex 1 53.56 Hippocampus 1 52.76 withdrawal 4 41.28 Arthritis 7 6.56 Infliximab 13 5.00

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 253 99.78 Syndrome 103 99.70 Hypergammaglobulinemia 11 99.64 Disease 175 98.64 Proteinuria 4 98.36 Acquired Immune Deficiency Syndrome Or Hiv Infection 32 97.84 Renal Failure 7 97.36 B-cell Lymphoma 9 96.68 Salivary Gland Disease 6 96.28 INFLAMMATION 25 94.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Increases in BLyS levels correlated with increased disease activity and were predictive of future disease activity, suggesting that BLyS may be a biomarker for SLE [17].

Positive_regulation (Increases) of BLyS associated with systemic lupus erythematosus and disease

1) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.99 Pain Relevance 0.04

In addition, after treatment with rituximab in SLE patients, BLyS levels significantly increase after B-cell depletion until repopulation with B cells occurs [25,44].

Positive_regulation (increase) of BLyS in B cells associated with systemic lupus erythematosus

2) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.34 Pain Relevance 0.11

Moreover, elevated BLyS blood levels have been found in some patients with SLE [15,16], and observational studies demonstrated that BLyS concentrations change over time in the majority of SLE patients [17,18].

Positive_regulation (elevated) of BLyS in blood associated with systemic lupus erythematosus

3) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.14 Pain Relevance 0.08

Especially, SS patients with elevated BAFF levels, hypergammaglobulinemia, elevated levels of autoantibodies, and associated B cell lymphoma might be candidates for anti-BAFF treatment [33].

Positive_regulation (elevated) of BAFF in B cell associated with b-cell lymphoma, hypergammaglobulinemia and syndrome

4) Confidence 0.36 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 0.75 Pain Relevance 0.05

In humans, circulating BAFF levels are increased in patients with pSS and correlate with disease activity [11].

Positive_regulation (increased) of BAFF associated with disease

5) Confidence 0.36 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 1.88 Pain Relevance 0.11

BAFF levels were found elevated in serum and saliva in SS patients, but no correlation could be shown between serum and saliva levels [30].

Positive_regulation (elevated) of BAFF in saliva associated with syndrome

6) Confidence 0.36 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 0.77 Pain Relevance 0.03

BLyS levels could not be measured because the presence of belimumab in the blood interfered with the detection of BLyS.

Neg (not) Positive_regulation (measured) of BLyS in blood

7) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0 Pain Relevance 0

Elevated BAFF plasma levels have only been reported in chronically HIV-infected patients with a low CD4 count [46], [47].

Positive_regulation (Elevated) of BAFF in plasma associated with acquired immune deficiency syndrome or hiv infection

8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.53 Pain Relevance 0.13

Elevated serum levels of BAFF and APRIL have been reported in patients with systemic lupus erythematosus (SLE).

Positive_regulation (Elevated) of BAFF associated with systemic lupus erythematosus

9) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.73 Pain Relevance 0.15

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