INT215493

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 100.00 Very High Very High Very High
dorsal root ganglion 77 99.60 Very High Very High Very High
antagonist 3 97.04 Very High Very High Very High
Spinal cord 6 91.68 High High
Neuropathic pain 13 89.24 High High
Brush evoked pain 19 86.44 High High
Kinase C 72 85.68 High High
Eae 4 84.00 Quite High
Peripheral nerve injury 10 64.00 Quite High
Root ganglion neuron 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 78 99.60 Very High Very High Very High
Neuropathic Pain 35 89.24 High High
Injury 5 84.00 Quite High
Nervous System Injury 47 71.56 Quite High
Hepatitis 2 69.72 Quite High
Pain 13 41.80 Quite Low
INFLAMMATION 2 41.60 Quite Low
Hyperalgesia 1 21.28 Low Low
Nociception 6 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP receptor agonist-dependent phosphorylation of cPLA2 and CaMKII were inhibited either by the selective P2X3R/P2X2+3R antagonist A-317491 or by the nonselective VDCC blocker cadmium.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of ATP receptor associated with antagonist and agonist
1) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.20 Pain Relevance 0.92
54 kDa of the P2X2 or P2X3 subunit, respectively, the presence of which could be verified by immunoblotting (right panel)

PMA or calyculin A do not enhance phosphorylation of P2X3 receptors in intact HEK cells

Neg (not) Positive_regulation (enhance) of Phosphorylation (phosphorylation) of P2X3
2) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.07 Pain Relevance 0.22

General Comments

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