INT215499

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 144 99.98 Very High Very High Very High
bradykinin 5 98.64 Very High Very High Very High
substance P 5 95.28 Very High Very High Very High
Glutamate receptor 3 91.28 High High
Inflammatory mediators 1 86.44 High High
Inflammation 9 84.24 Quite High
Stimulus evoked pain 5 76.04 Quite High
allodynia 17 61.64 Quite High
Neuropathic pain 34 52.08 Quite High
Peripheral nerve injury 6 50.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 86.04 High High
Hypersensitivity 10 76.04 Quite High
Inflammatory Pain 10 75.36 Quite High
Neuropathic Pain 72 61.64 Quite High
Nervous System Injury 44 49.84 Quite Low
Hyperalgesia 7 11.80 Low Low
Targeted Disruption 1 9.60 Low Low
Pain 43 8.36 Low Low
Nociception 11 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying mechanism, however, is unlikely to involve direct PKC-mediated phosphorylation of P2X receptors.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of P2X associated with kinase c
1) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.28
Further evidence against a direct PKC-mediated P2X receptor phosphorylation comes from co-expression studies of P2X1 and G protein-coupled receptors.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of P2X associated with kinase c
2) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.33
Some of the regulation is mediated through the phosphorylation of P2X receptors by protein kinases [117, 118].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of P2X
3) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.57 Pain Relevance 0.46

General Comments

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