INT21550

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.58
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr1737)
Anatomy Link Frequency
PVN 2
TM3 1
Olr1737 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 11 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
MU agonist 2 100.00 Very High Very High Very High
Pain 4 99.74 Very High Very High Very High
Pain threshold 8 99.62 Very High Very High Very High
Glutamate 10 97.34 Very High Very High Very High
antagonist 8 96.88 Very High Very High Very High
narcan 3 96.08 Very High Very High Very High
Opioid 2 93.08 High High
Intracerebroventricular 1 91.00 High High
Disease Link Frequency Relevance Heat
Pain 12 99.74 Very High Very High Very High
Stress 5 94.24 High High
Adhesions 3 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that electrical stimulation of the PVN increased the pain threshold, and L-glutamate sodium injection into the PVN elevated the pain threshold, but the PVN cauterization decreased the pain threshold; pain stimulation raised the arginine vasopressin (AVP), not oxytocin (OXT), leucine-enkephalin (L-Ek), beta-endorphin (beta-Ep) and DynorphinA1-13 (DynA1-13) concentrations in the PVN tissue using micropunch method, heightened AVP, L-Ek, beta-Ep and DynA1-13, not OXT concentrations in the PVN perfuse liquid, and reduced the number of AVP-, not OXT, L-Ek, beta-Ep and DynA1-13-immunoreactive neurons in the PVN especially in the posterior magnocellular part of the PVN using immunocytochemistry.
Gene_expression (concentrations) of DynA1-13 in PVN associated with pain, glutamate, pain threshold and enkephalin
1) Confidence 0.03 Published 2006 Journal Brain Res. Section Abstract Doc Link 16409991 Disease Relevance 0.52 Pain Relevance 1.30
The results showed that electrical stimulation of the PVN increased the pain threshold, and L-glutamate sodium injection into the PVN elevated the pain threshold, but the PVN cauterization decreased the pain threshold; pain stimulation raised the arginine vasopressin (AVP), not oxytocin (OXT), leucine-enkephalin (L-Ek), beta-endorphin (beta-Ep) and DynorphinA1-13 (DynA1-13) concentrations in the PVN tissue using micropunch method, heightened AVP, L-Ek, beta-Ep and DynA1-13, not OXT concentrations in the PVN perfuse liquid, and reduced the number of AVP-, not OXT, L-Ek, beta-Ep and DynA1-13-immunoreactive neurons in the PVN especially in the posterior magnocellular part of the PVN using immunocytochemistry.
Gene_expression (raised) of DynA1-13 in PVN associated with pain, glutamate, pain threshold and enkephalin
2) Confidence 0.03 Published 2006 Journal Brain Res. Section Abstract Doc Link 16409991 Disease Relevance 0.54 Pain Relevance 1.48
Studies with smaller molecular weight forms of ACTH (in a dose equimolar to 10 micrograms of ACTH1-39) revealed that ACTH1-13 and ACTH1-10 were also protective.
Gene_expression (protective) of ACTH1-13
3) Confidence 0.02 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2176916 Disease Relevance 0.35 Pain Relevance 0.17
Mutation of Asn150 in TM3 produces a three- to 20-fold increase in affinity for the opioid agonists morphine, DAMGO, fentanyl, beta-endorphin1-31, JOM-13, deltorphin II, dynorphin1-13, and U50,488, with no change in the binding of antagonists such as naloxone, naltrexone, naltrindole, and nor-binaltorphamine.
Gene_expression (produces) of JOM-13 in TM3 associated with mu agonist, antagonist, narcan and morphine
4) Confidence 0.01 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 8978745 Disease Relevance 0 Pain Relevance 0.67
Upon transfection of Cos 1 cells with SG13 and DUZ-1 cDNAs, the OBCAM-homologous proteins were expressed on the surface of the Cos 1 cells.
Gene_expression (transfection) of SG13
5) Confidence 0.01 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8965653 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox