INT215501

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 32 98.96 Very High Very High Very High
Potency 27 97.12 Very High Very High Very High
adenocard 3 81.80 Quite High
Pain 9 70.64 Quite High
Neurotransmitter 2 69.44 Quite High
Kinase C 144 55.92 Quite High
substance P 4 49.84 Quite Low
bradykinin 4 48.56 Quite Low
Calcitonin gene-related peptide 4 44.80 Quite Low
antagonist 16 35.84 Quite Low
Disease Link Frequency Relevance Heat
Nociception 10 81.28 Quite High
Pathologic Processes 2 78.00 Quite High
Pain 9 70.64 Quite High
Nervous System Injury 6 46.88 Quite Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Hemorrhage 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A peculiar phenotype is inherent to heteromeric P2X2/P2X3 (P2X2+3) receptors, which feature ??
Positive_regulation (inherent) of P2X2 Binding (heteromeric) of
1) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.30 Pain Relevance 0.22
A peculiar phenotype is inherent to heteromeric P2X2/P2X3 (P2X2+3) receptors, which feature ??
Positive_regulation (inherent) of P2X2 Binding (heteromeric) of
2) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.31 Pain Relevance 0.22
Mutants generated on P2X1 and P2X2 receptor backgrounds showed that residues Lys68, Lys70, Arg292 and Lys309 contribute to ATP potency (P2X1 receptor numbering)(Ennion et al., 2000; Jiang et al., 2000); with the greatest, >1000-fold, decreases in ATP sensitivity for Lys68Ala and Lys309Ala mutants at the P2X1 receptor (Ennion et al., 2000).
Positive_regulation (generated) of P2X2 Binding (backgrounds) of associated with potency
3) Confidence 0.23 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.11

General Comments

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