INT215521

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.68
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
sensory neuron 1
plasma 1
adipose tissue 1
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 73 98.96 Very High Very High Very High
adenocard 106 98.12 Very High Very High Very High
Visceral pain 2 96.20 Very High Very High Very High
Analgesic 3 95.28 Very High Very High Very High
agonist 72 95.04 Very High Very High Very High
tolerance 49 90.80 High High
Perioperative pain 1 90.68 High High
Glutamate receptor 6 87.84 High High
Lasting pain 4 86.60 High High
antagonist 47 84.24 Quite High
Disease Link Frequency Relevance Heat
Obesity 18 99.84 Very High Very High Very High
Body Weight 66 97.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 96.20 Very High Very High Very High
Pressure And Volume Under Development 52 95.12 Very High Very High Very High
Insulin Resistance 24 94.60 High High
Repression 1 94.00 High High
Impaired Glucose Tolerance 60 90.80 High High
Post Operative Pain 1 90.68 High High
Nociception 33 88.88 High High
Pain 15 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, the inhibitory effects of nucleotides on sensory neuron function were enhanced by the blockade of P2Y1.
Negative_regulation (blockade) of P2Y1 in sensory neuron
1) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.13 Pain Relevance 0.49
P2Y1 deficiency was found to result in increases in glycemia and insulinemia in the nonfasting state, associated with increased body weight and decreased plasma levels of free fatty acids and triglycerides.
Negative_regulation (deficiency) of P2Y1 in plasma associated with body weight
2) Confidence 0.43 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.30 Pain Relevance 0.07
In this study, we investigated the effects of P2Y1 deficiency on the regulation of glucose homeostasis in mice.
Spec (investigated) Negative_regulation (deficiency) of P2Y1
3) Confidence 0.43 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.12 Pain Relevance 0
Concerning the mechanism of the decrease in plasma FFA, a direct effect of P2Y1 receptor depletion in adipose tissue or in the liver cannot be excluded but would appear to be unlikely.
Negative_regulation (depletion) of P2Y1 in adipose tissue associated with obesity
4) Confidence 0.43 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.58 Pain Relevance 0.05
The effect of P2Y1 deficiency on glycemia was assessed according to the nutritional status of the animals.
Negative_regulation (deficiency) of P2Y1
5) Confidence 0.43 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.28 Pain Relevance 0.05
-cell function is improved in P2Y1-deficient mice, particularly in the presence of high glucose concentrations, pointing to a putative inhibitory effect of the P2Y1 receptor on insulin secretion.
Negative_regulation (effect) of P2Y1
6) Confidence 0.42 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.13 Pain Relevance 0.07
All these data disagree with our observation that absence of the P2Y1 receptor contributes to increase insulin secretion instead of decreasing it.
Negative_regulation (absence) of P2Y1
7) Confidence 0.42 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.09
Examples of these include Fzd1, Htr2b, Gpr84 (induced by LPS, Table 3), and P2ry1 and 5 (repressed by LPS, Table 4).
Negative_regulation (include) of P2ry1
8) Confidence 0.36 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0
In addition to the unspecific blockers of P2 receptors, suramin and PPADS, the P2Y1-specific inhibitor, MRS2179, efficiently suppressed the effects of glutamate and ATP, suggesting that ADP resulting from the action of ectoapyrases activates P2Y1 receptors on Müller cells.
Negative_regulation (inhibitor) of P2Y1 associated with glutamate
9) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.28 Pain Relevance 0.52
Whereas inhibition of P2Y1 prevented the effects of glutamate and ATP, it did not alter the action of adenosine.
Negative_regulation (inhibition) of P2Y1 associated with adenocard and glutamate
10) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.07 Pain Relevance 0.75
-bisphosphate) was discovered as a specific inhibitor of P2Y1 receptor activity [194].
Negative_regulation (inhibitor) of P2Y1 receptor
11) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.51 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox