INT215594

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.46
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
spinal 4
nerve 2
dorsal horn 2
microglia 2
hippocampus 2
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 61 100.00 Very High Very High Very High
Dorsal horn 47 100.00 Very High Very High Very High
Hippocampus 28 100.00 Very High Very High Very High
Peripheral nerve injury 15 100.00 Very High Very High Very High
Neuropathic pain 123 99.76 Very High Very High Very High
intrathecal 21 99.20 Very High Very High Very High
Brush evoked pain 55 98.22 Very High Very High Very High
adenocard 25 97.48 Very High Very High Very High
Pain 87 93.68 High High
Glutamate 20 91.24 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 90 100.00 Very High Very High Very High
Convulsion 6 100.00 Very High Very High Very High
Neuropathic Pain 225 99.76 Very High Very High Very High
Muscle Weakness 2 99.32 Very High Very High Very High
Hypertrophy 3 96.24 Very High Very High Very High
Pain 108 93.68 High High
Targeted Disruption 20 89.80 High High
Epilepsy 8 80.72 Quite High
Infection 12 80.56 Quite High
Diabetes Mellitus 8 80.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, intrathecally administered antisense oligodeoxynucleotide for P2X4R reduced the expression of P2X4 protein in spinal microglia and prevented the development of the nerve injury-induced tactile allodynia.
Negative_regulation (reduced) of Gene_expression (expression) of P2X4 in nerve associated with brush evoked pain and nervous system injury
1) Confidence 0.48 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.06 Pain Relevance 0.89
The expression of P2X4 receptors in the spinal cord is enhanced in spinal microglia after peripheral nerve injury, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain behaviour.
Negative_regulation (blocking) of Gene_expression (expression) of P2X4 in spinal associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
2) Confidence 0.42 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096535 Disease Relevance 1.19 Pain Relevance 1.06
The expression of P2X4 receptors in the spinal cord is enhanced in spinal microglia after peripheral nerve injury, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain behaviour.
Negative_regulation (suppressing) of Gene_expression (expression) of P2X4 in spinal associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
3) Confidence 0.42 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096535 Disease Relevance 1.19 Pain Relevance 1.07
Moreover, it was found that reducing the expression of P2X4 protein in spinal microglia by means of intrathecally administered antisense oligodeoxynucleotide targeting P2X4R prevented the development of the nerve injury-induced tactile allodynia.
Negative_regulation (reducing) of Gene_expression (expression) of P2X4 protein in microglia associated with brush evoked pain and nervous system injury
4) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.13 Pain Relevance 0.82
Crystalization of the zebra fish P2X4 receptor
Negative_regulation (zebra fish) of Gene_expression (receptor) of P2X4
5) Confidence 0.16 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0
Activation of dorsal horn microglia and tactile allodynia developing several days after ligation of a spinal nerve were greatly reduced when gene expression of P2X4 receptor in the dorsal horn had been inhibited by the presence of intrathecal antisense oligonucleotides [150].
Negative_regulation (inhibited) of Gene_expression (expression) of P2X4 in dorsal horn associated with brush evoked pain, dorsal horn and intrathecal
6) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.02 Pain Relevance 0.90
P2X2 and P2X4 receptor expression in the hippocampus of seizure-prone gerbils was significantly reduced compared with that of normal gerbils [139].
Negative_regulation (reduced) of Gene_expression (expression) of P2X4 in hippocampus associated with convulsion and hippocampus
7) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.87 Pain Relevance 0.48

General Comments

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