INT215596

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) plasma membrane (Slc12a5) intracellular (Slc12a5)
cytoplasmic membrane-bounded vesicle (Bdnf) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 2
Bdnf (Rattus norvegicus)
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 7 100.00 Very High Very High Very High
chemokine 1 99.88 Very High Very High Very High
cytokine 7 99.28 Very High Very High Very High
gABA 3 99.04 Very High Very High Very High
Spinal cord 7 90.12 High High
Neuropathic pain 35 87.36 High High
Dorsal horn neuron 3 85.04 High High
Brush evoked pain 10 78.64 Quite High
hyperexcitability 1 78.56 Quite High
Pain 15 75.60 Quite High
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Nervous System Injury 10 90.88 High High
Neuropathic Pain 51 87.36 High High
Pain 14 75.60 Quite High
Cancer 3 28.00 Quite Low
Necrosis 1 27.52 Quite Low
INFLAMMATION 5 6.92 Low Low
Injury 7 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF causes a collapse of transmembrane anion gradient in dorsal horn lamina I neurons presumably through the downregulation of KCC2, which in turn renders GABA and glycine effects depolarizing, rather than hyperpolarizing, in these neurons.
BDNF Positive_regulation (causes) of Negative_regulation (downregulation) of KCC2 in neurons associated with gaba, shock and dorsal horn
1) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.76 Pain Relevance 0.86

General Comments

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