INT215598

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.44
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx7, TNF) cell morphogenesis (P2rx7) intracellular (TNF)
mitochondrion organization (P2rx7) extracellular matrix organization (TNF) protein complex (P2rx7)
Anatomy Link Frequency
neuron 3
P2rx7 (Rattus norvegicus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 5 100.00 Very High Very High Very High
Inflammation 5 96.24 Very High Very High Very High
Pain 15 94.96 High High
Neuropathic pain 35 89.80 High High
cytokine 7 75.84 Quite High
antagonist 1 68.96 Quite High
Spinal cord 7 46.64 Quite Low
Eae 1 39.08 Quite Low
Hyperalgesia 1 38.00 Quite Low
Dorsal horn 7 20.72 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 100.00 Very High Very High Very High
INFLAMMATION 5 96.24 Very High Very High Very High
Neuropathic Pain 51 95.56 Very High Very High Very High
Pain 14 94.96 High High
Targeted Disruption 3 76.40 Quite High
Nociception 1 62.80 Quite High
Hypersensitivity 2 59.32 Quite High
Injury 7 50.64 Quite High
Hyperalgesia 1 38.00 Quite Low
Nervous System Injury 10 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, a recent study has shown that activation of P2X7 receptors expressed on satellite glia that enwrap each DRG neuron leads to a release of TNF-?
Positive_regulation (activation) of P2X7 in neuron Positive_regulation (leads) of Localization (release) of TNF in neuron associated with dorsal root ganglion
1) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.44 Pain Relevance 0.85

General Comments

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