INT215599

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.29
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
vasculature 2
neurons 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 266 99.98 Very High Very High Very High
antinociception 10 99.96 Very High Very High Very High
gABA 19 99.00 Very High Very High Very High
antiallodynic 12 99.00 Very High Very High Very High
Antihyperalgesic 13 98.64 Very High Very High Very High
Antinociceptive 44 98.28 Very High Very High Very High
intrathecal 9 97.54 Very High Very High Very High
depression 20 95.64 Very High Very High Very High
Glutamate 15 95.60 Very High Very High Very High
ischemia 56 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 19 100.00 Very High Very High Very High
Depression 21 95.64 Very High Very High Very High
Coronary Artery Disease 4 95.04 Very High Very High Very High
Htlv Types I And Ii 78 91.04 High High
Pressure Volume 2 Under Development 28 89.04 High High
Hypoxia 17 89.04 High High
Myocardial Infarction 32 83.52 Quite High
Coronary Heart Disease 8 83.12 Quite High
Reperfusion Injury 8 69.36 Quite High
Cv Unclassified Under Development 53 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results from previous studies suggest that adenosine induces bradycardia by activation of A1AR.
Positive_regulation (induces) of Positive_regulation (activation) of A1AR associated with heart rate under development and adenocard
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.10 Pain Relevance 0.30
We previously found that a single intrathecal injection of PAP had antinociceptive, antihyperalgesic and antiallodynic effects that lasted for three days and that were dependent on A1R activation [10,11].
Positive_regulation (dependent) of Positive_regulation (activation) of A1R associated with antihyperalgesic, antiallodynic, antinociceptive and intrathecal
2) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.32
Note: an alternative hypothesis could be that A1R activation substantially increases extracellular levels of GABA and/or glycine thereby depressing the activity of postsynaptic neurons and thus depressing network activity.
Positive_regulation (increases) of Positive_regulation (activation) of A1R in neurons associated with gaba
3) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.15 Pain Relevance 0.19
And, just like hPAP and bPAP mediated antinociception, A1R receptor activation was required for mPAP mediated antinociception.
Positive_regulation (required) of Positive_regulation (activation) of A1R receptor associated with antinociception
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.46 Pain Relevance 0.91
Therefore, the cardioprotection of ATL313 in group 3 may be due to a preconditioning effect by activation of A1AR in a high dose with systemic hemodynamic effects, and not by pure activation of A2AAR.
Neg (not) Positive_regulation (activation) of Neg (not) Positive_regulation (activation) of A1AR
5) Confidence 0.16 Published 2009 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2811859 Disease Relevance 0.85 Pain Relevance 0.11
Whether cardioprotection by ATL313 is due to its actions on the vasculature, or through the preconditioning effect by stimulating A1AR, will require further investigation.



Positive_regulation (due) of Positive_regulation (stimulating) of A1AR in vasculature
6) Confidence 0.16 Published 2009 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2811859 Disease Relevance 0.64 Pain Relevance 0.16
Regarding A1Rs and A2ARs, basal conditions generate a low tone of endogenous adenosine and cause A1R activation, in contrast to situations of increased adenosine where A2AR activation becomes dominant.
Positive_regulation (cause) of Positive_regulation (activation) of A1R associated with adenocard
7) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.09 Pain Relevance 0.59

General Comments

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