INT2156

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2004
Negated 2
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 3.18
Pain Relevance 14.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 4
plasma 2
RVLM 2
forebrain 2
MBH 2
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 110 100.00 Very High Very High Very High
opiate 35 100.00 Very High Very High Very High
cytokine 6 100.00 Very High Very High Very High
Clonidine 3 100.00 Very High Very High Very High
Locus ceruleus 3 100.00 Very High Very High Very High
Morphine 30 99.98 Very High Very High Very High
anesthesia 4 99.88 Very High Very High Very High
Enkephalin 4 99.78 Very High Very High Very High
agonist 6 99.42 Very High Very High Very High
gABA 2 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 9 98.16 Very High Very High Very High
Urological Neuroanatomy 12 96.20 Very High Very High Very High
INFLAMMATION 3 91.04 High High
Pain 3 84.08 Quite High
Body Weight 1 82.00 Quite High
Pressure And Volume Under Development 1 79.16 Quite High
Frailty 1 77.56 Quite High
Rheumatoid Arthritis 1 75.60 Quite High
Hypertension 5 75.00 Quite High
Congenital Anomalies 1 74.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 32-week OVX rats, even the lower-dose naloxone did not induce an elevation in mean LH levels.
Neg (not) Positive_regulation (induce) of Positive_regulation (elevation) of LH associated with narcan
1) Confidence 0.69 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2118607 Disease Relevance 0.06 Pain Relevance 0.32
Administration of LHRH induced a 7-fold increase in plasma LH levels in both the pituitary-grafted animals and the sham-operated controls.
Positive_regulation (induced) of Positive_regulation (increase) of LH in pituitary
2) Confidence 0.68 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 3895021 Disease Relevance 0.15 Pain Relevance 0.51
However, the increases of serum LH levels induced by the combined treatment were in both instances lower than those produced by the administration of either drug alone.
Positive_regulation (increases) of Positive_regulation (induced) of LH
3) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3010157 Disease Relevance 0.06 Pain Relevance 0.90
This is supported by the finding that whereas combined bromocriptine (500 micrograms) and GnRH (25 ng) treatment suppressed the suckling-induced prolactin rise and also induced only a small progressive increase in LH (similar to GnRH alone), combined naloxone (500 micrograms) and GnRH (25 ng) treatment induced a sharp sixfold increase in LH levels within 15 min while at the same time markedly suppressing prolactin levels.
Positive_regulation (induced) of Positive_regulation (increase) of LH associated with narcan
4) Confidence 0.58 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.27
Naloxone (500 micrograms), however, induced a twofold increase in LH levels within 15 min suggesting that an enhanced opiate rather than dopaminergic activity may be responsible for the suppression of GnRH and hence gonadotrophin secretion during suckling.
Positive_regulation (induced) of Positive_regulation (increase) of LH associated with narcan and opiate
5) Confidence 0.58 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.42
These results suggest that naloxone-induced increase in LH release is mediated via a noradrenergic mechanism.
Positive_regulation (mediated) of Positive_regulation (increase) of LH associated with narcan
6) Confidence 0.50 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6307711 Disease Relevance 0 Pain Relevance 0.40
These results suggest that naloxone-induced increase in LH release is mediated via a noradrenergic mechanism.
Positive_regulation (naloxone-induced) of Positive_regulation (increase) of LH associated with narcan
7) Confidence 0.50 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6307711 Disease Relevance 0 Pain Relevance 0.40
Quite unexpectedly, the three peptides, instead of exerting an inhibitory effect, enhanced the LH response to NMDA.
Positive_regulation (enhanced) of Positive_regulation (response) of LH
8) Confidence 0.49 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7827626 Disease Relevance 0 Pain Relevance 0.78
Since depletion of HPOA-EPIN by LY 134046 did not compromise the LH response to naloxone, this effect of FLA-63 is due to depletion of HPOA-NE levels. 3) While saline had no effect on the increased pulsatile LH release caused by naloxone, administration of baclofen (GABA-B receptor agonist, 6 mg/kg IV) suppressed the pulsatile LH secretory response to naloxone infusion.
Positive_regulation (pulsatile) of Positive_regulation (response) of LH in HPOA associated with gaba, agonist and narcan
9) Confidence 0.48 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2790494 Disease Relevance 0 Pain Relevance 0.46
We conclude that, under our conditions, induction of the LH deficit in escape performance is not opiate-mediated although its expression is opiate-modulated.
Positive_regulation (mediated) of Positive_regulation (induction) of LH associated with opiate
10) Confidence 0.47 Published 1997 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9292116 Disease Relevance 0.20 Pain Relevance 1.26
Furthermore, whereas the release of LH induced by intraventricular injection of norepinephrine in intact rats was enhanced by treatment with propranolol, in rats with PM cuts the already enhanced induced release was no further raised by propranolol treatment.
Positive_regulation (enhanced) of Positive_regulation (induced) of LH
11) Confidence 0.47 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6813756 Disease Relevance 0 Pain Relevance 0.10
Naloxone induced a significant rise in LH levels on the day of oestrus, dioestrus day-1 and dioestrus day-2; this response was blunted on the morning of pro-oestrus and absent in the afternoon and after acute and chronic OB treatment.
Positive_regulation (induced) of Positive_regulation (rise) of LH associated with narcan
12) Confidence 0.46 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3003224 Disease Relevance 0 Pain Relevance 0.39
Similarly, in estrogen-primed females but not males, progesterone induced a presurge sequential accumulation and decline of LH-releasing hormone (LH-RH) concentrations in the median eminence and increased the turnover rates of norepinephrine (NE) and epinephrine (E) in the medial basal hypothalamus during the time of LH-RH accumulation.
Positive_regulation (increased) of Positive_regulation (accumulation) of LH in median eminence
13) Confidence 0.46 Published 1988 Journal Brain Res. Section Abstract Doc Link 3052697 Disease Relevance 0 Pain Relevance 0.44
Blockade of the opiate system by naltrexone caused a sharp increase of LH levels in normoglycemic rats, while only a gradual decrease was observed in hyperglycemic animals.
Positive_regulation (caused) of Positive_regulation (increase) of LH associated with opiate
14) Confidence 0.44 Published 1985 Journal Life Sci. Section Abstract Doc Link 4033351 Disease Relevance 0.76 Pain Relevance 0.40
These results suggest that the NAL-induced increase in LH release is mediated in part via a hypothalamic noradrenergic mechanism.
Positive_regulation (mediated) of Positive_regulation (increase) of LH associated with narcan
15) Confidence 0.43 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 7301047 Disease Relevance 0 Pain Relevance 0.33
Chronic exposure (4 days) to morphine enhanced both the inhibitory effects of E2 on LH secretion at 1000 h and E2 induction of the midafternoon surge in LH.
Positive_regulation (enhanced) of Positive_regulation (induction) of LH associated with morphine
16) Confidence 0.42 Published 1987 Journal Endocrinology Section Abstract Doc Link 3032570 Disease Relevance 0 Pain Relevance 0.57
These data indicate clearly that the increased plasma LH levels observed after in vivo PGE injection are secondary to a stimulation of LH-RH release while PGEs do not appear to have a significant effect on LH release at the pituitary level.
Positive_regulation (stimulation) of Positive_regulation (increased) of LH in plasma
17) Confidence 0.42 Published 1976 Journal Prostaglandins Section Abstract Doc Link 772758 Disease Relevance 0 Pain Relevance 0.13
The treatment of male rats with naloxone was without any effect on LH release before puberty (at 16 and 26 days of age), but induced a significant increase of serum LH titers after sexual maturation (60 days).
Positive_regulation (induced) of Positive_regulation (increase) of LH associated with narcan
18) Confidence 0.42 Published 1989 Journal Endocrinology Section Abstract Doc Link 2912695 Disease Relevance 0 Pain Relevance 0.64
The decrease in proenkephalin mRNA in the NTS, CVLM, and RVLM may attenuate arterial baroreceptor reflex activity, while the increase in proenkephalin mRNA in the LC, AH and LH may increase sympathetic tone by inhibiting the activity of sympathodepressor preganglionic neurons in the intermediolateral cell column of the spinal cord.
Spec (may) Positive_regulation (increase) of Positive_regulation (increase) of LH in RVLM associated with rostral ventrolateral medulla, locus ceruleus, urological neuroanatomy and spinal cord
19) Confidence 0.42 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968371 Disease Relevance 0.43 Pain Relevance 0.32
The peak increase in serum LH occurred 20 min after the injection.
Positive_regulation (occurred) of Positive_regulation (increase) of LH
20) Confidence 0.41 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.50

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