INT215601

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.74
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
neurons 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 306 100.00 Very High Very High Very High
addiction 3 100.00 Very High Very High Very High
Antinociceptive 44 99.64 Very High Very High Very High
Substantia nigra 5 98.04 Very High Very High Very High
Neuropathic pain 4 97.84 Very High Very High Very High
IPN 10 96.32 Very High Very High Very High
Thalamus 1 95.28 Very High Very High Very High
depression 122 92.48 High High
gABA 55 91.36 High High
antinociception 10 89.80 High High
Disease Link Frequency Relevance Heat
Depression 129 99.76 Very High Very High Very High
Neuropathic Pain 6 97.84 Very High Very High Very High
Nervous System Injury 6 96.80 Very High Very High Very High
Inflammatory Pain 10 96.32 Very High Very High Very High
Nociception 13 92.28 High High
Targeted Disruption 5 91.52 High High
Convulsion 44 91.20 High High
Hyperalgesia 3 89.28 High High
Heart Rate Under Development 19 84.40 Quite High
Sleep Disorders 4 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is some evidence that activation of A1Rs is also involved in GABAA receptor downregulation, implying a facilitation of the neurotransmission on a postsynaptic site.
Regulation (involved) of Positive_regulation (activation) of A1R
1) Confidence 0.60 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.83
Thus, A1AR activation counteracts the effect of the ?
Regulation (effect) of Positive_regulation (activation) of A1AR
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.30 Pain Relevance 0.23
In other neurons A1R activation affects Ca++ conductance [17,25,48].
Regulation (affects) of Positive_regulation (activation) of A1R in neurons
3) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0.05
Since GABAAergic and glycinergic transmission affect the pattern of pre-BötC output, the effect of A1R activation on inputs via these transmitters was examined as proxy for the effects of A1R activation on fast chemical transmission in general.
Spec (examined) Regulation (effect) of Positive_regulation (activation) of A1R
4) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.15 Pain Relevance 0.22
Effects of A1R activation on synaptic inputs
Regulation (Effects) of Positive_regulation (activation) of A1R
5) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.09 Pain Relevance 0
Effects of A1R activation on membrane properties
Regulation (Effects) of Positive_regulation (activation) of A1R
6) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0
That is, do the postsynaptic potentials evoked by GABAA, or GABAA and glycine receptor activation integrate synergistically with the depressive modulatory effects of A1R activation?
Regulation (effects) of Positive_regulation (activation) of A1R associated with depression
7) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.24 Pain Relevance 0.05
We used wild-type (WT) and A1R-/- mice, to evaluate dependence on A1R activation.
Regulation (dependence) of Positive_regulation (activation) of A1R associated with addiction
8) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.71 Pain Relevance 0.73
To verify that NCPA directly affected A1R activation in the cells examined, rather than affecting release of other substances onto the patched cells, we repeated the preceding set of experiments (minus the measurement of INa) in the presence of TTX, Cd++, elevated Mg++ and minimal extracellular Ca++ (as close to no Ca++ as possible).
Regulation (affected) of Positive_regulation (activation) of A1R
9) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0
Since GABAAergic and glycinergic transmission affect the pattern of pre-BötC output, the effect of A1R activation on inputs via these transmitters was examined as proxy for the effects of A1R activation on fast chemical transmission in general.
Spec (examined) Regulation (effects) of Positive_regulation (activation) of A1R
10) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.15 Pain Relevance 0.19
When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A1-adenosine receptor (A1R) activation.
Regulation (dependent) of Positive_regulation (activation) of A1-adenosine receptor associated with adenocard and antinociceptive
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617779 Disease Relevance 0.09 Pain Relevance 0.35

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