INT215604

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.47
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
neuronal 1
brain 1
basal ganglia 1
prefrontal 1
interneurons 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 329 99.82 Very High Very High Very High
Central nervous system 81 99.72 Very High Very High Very High
Neuropeptide 40 99.20 Very High Very High Very High
adenocard 818 98.24 Very High Very High Very High
Hippocampus 114 98.12 Very High Very High Very High
Dopamine 72 97.60 Very High Very High Very High
Glutamate 114 96.20 Very High Very High Very High
amygdala 16 94.40 High High
antagonist 177 92.96 High High
dopamine receptor 17 83.44 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 18 97.52 Very High Very High Very High
Disease 54 96.24 Very High Very High Very High
Anxiety Disorder 9 95.80 Very High Very High Very High
Drug Induced Neurotoxicity 16 91.52 High High
Hypoxia 79 83.12 Quite High
Urological Neuroanatomy 8 80.08 Quite High
Targeted Disruption 8 74.44 Quite High
Depression 60 69.12 Quite High
Parkinson's Disease 8 65.36 Quite High
Stress 4 33.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2Y1R signaling occurs in non-neuronal and non-muscular cell types, as well as on neurons in the CNS [63] where a colocalization of A1Rs and P2Y1Rs was demonstrated immunohistochemically in rat brain cortex, hippocampus, and cerebellum [64].
Localization (colocalization) of A1R in neuronal associated with hippocampus and central nervous system
1) Confidence 0.78 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.34
Although colocalization of A1Rs and P2Y1Rs in several brain areas has been demonstrated, there is still a lack of functional investigations.
Localization (colocalization) of A1R in brain
2) Confidence 0.78 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.10 Pain Relevance 0.52
In vivo and in vitro data on adenosine-dopamine interactions were mostly obtained from investigations in the basal ganglia and limbic regions [52, 53] due to the high abundance of A1Rs, A2ARs, D1Rs, and D2Rs in these areas and their involvement in the pathology of Parkinson’s disease.
Localization (abundance) of A1R in basal ganglia associated with dopamine, adenocard and disease
3) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.28 Pain Relevance 0.46
All in all, these results suggest that the extent and the kinetics of agonist-induced desensitization of A1Rs depend on the subcellular localization of the receptors [40].
Localization (desensitization) of A1R associated with agonist
4) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.15 Pain Relevance 0.26
The activation of hippocampal A3Rs induced a desensitization of A1Rs on combined superfusion of Cl-IB-MECA and adenosine.
Localization (desensitization) of A1R associated with adenocard
5) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.22
Relationship between A1Rs and NPY
Localization (Relationship) of A1R
6) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.29 Pain Relevance 0.56
In this study, the functionality of A1Rs was not affected by NMDA preconditioning, but this treatment promoted A2AR desensitization in concert with A1R activation [83].
Localization (desensitization) of A1R
7) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.17 Pain Relevance 0.55
Relationship between A1Rs and A3Rs
Localization (Relationship) of A1R
8) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.05
Both A1Rs and Y1Rs are located on neurons of the prefrontal cortex, and their activation inhibits glutamatergic neurotransmission [62].
Localization (located) of A1R in prefrontal
9) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.24 Pain Relevance 0.24
It is possible that one or more of types of these conductances were affected by A1R, but in combination with whole cell K+ conductances such changes were insufficient to affect total transmembrane current.
Localization (affected) of A1R
10) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0.05
In fact, imunohistochemical data suggest that A1R are found at the axon terminals of interneurons within a variety of CNS regions, including the NTS where they may be involved in regulating transmitter release [47].
Localization (found) of A1R in interneurons
11) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.18 Pain Relevance 0.24

General Comments

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