INT215606

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 157 99.98 Very High Very High Very High
Neuropeptide 10 99.20 Very High Very High Very High
Dopamine 18 97.60 Very High Very High Very High
adenocard 244 95.36 Very High Very High Very High
antagonist 53 92.64 High High
Substantia nigra 10 75.00 Quite High
dopamine receptor 5 53.76 Quite High
Hippocampus 30 37.76 Quite Low
Glutamate 28 29.48 Quite Low
amygdala 4 24.72 Low Low
Disease Link Frequency Relevance Heat
Disease 18 84.96 Quite High
Hypoxia 21 83.12 Quite High
Urological Neuroanatomy 2 80.08 Quite High
Bordatella Infection 6 63.20 Quite High
Parkinson's Disease 2 62.28 Quite High
Adhesions 2 30.32 Quite Low
Anxiety Disorder 3 21.60 Low Low
Cancer 11 5.00 Very Low Very Low Very Low
Neurological Disease 10 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relationship between A1Rs and NPY
Positive_regulation (between) of Localization (Relationship) of A1R
1) Confidence 0.49 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.29 Pain Relevance 0.56
Relationship between A1Rs and A3Rs
Positive_regulation (between) of Localization (Relationship) of A1R
2) Confidence 0.49 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.05
All in all, these results suggest that the extent and the kinetics of agonist-induced desensitization of A1Rs depend on the subcellular localization of the receptors [40].
Positive_regulation (induced) of Localization (desensitization) of A1R associated with agonist
3) Confidence 0.49 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.15 Pain Relevance 0.26

General Comments

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