INT215607

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
hippocampus 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 54 99.98 Very High Very High Very High
Hippocampus 28 98.52 Very High Very High Very High
adenocard 184 98.24 Very High Very High Very High
Kinase C 2 89.52 High High
antagonist 36 88.44 High High
Central nervous system 20 84.12 Quite High
Pyramidal cell 14 83.28 Quite High
Glutamate 28 75.92 Quite High
gABA 26 5.00 Very Low Very Low Very Low
Dopamine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 16 41.04 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Neurological Disease 10 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 4 5.00 Very Low Very Low Very Low
Ataxia 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of hippocampal A3Rs induced a desensitization of A1Rs on combined superfusion of Cl-IB-MECA and adenosine.
Positive_regulation (induced) of Negative_regulation (desensitization) of A1R associated with adenocard
1) Confidence 0.45 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.22
A2AR activation by agonists caused A1R desensitization resulting in decreased binding affinity for CPA in the hippocampus in young adult rats.
Positive_regulation (caused) of Negative_regulation (desensitization) of A1R in hippocampus associated with agonist and hippocampus
2) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.41

General Comments

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