INT215608

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.35
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
hippocampus 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 421 100.00 Very High Very High Very High
agonist 122 100.00 Very High Very High Very High
antagonist 76 100.00 Very High Very High Very High
nMDA receptor 24 100.00 Very High Very High Very High
Glutamate 56 99.92 Very High Very High Very High
Hippocampus 56 99.62 Very High Very High Very High
Neurotransmitter 12 97.20 Very High Very High Very High
ischemia 99 95.28 Very High Very High Very High
Central nervous system 40 94.48 High High
Kinase C 5 86.08 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 99.88 Very High Very High Very High
Cv Unclassified Under Development 94 95.28 Very High Very High Very High
Bordatella Infection 8 85.12 High High
Drug Induced Neurotoxicity 8 73.44 Quite High
Hypoxia 40 70.56 Quite High
Acute Renal Failure 10 57.20 Quite High
INFLAMMATION 29 57.04 Quite High
Death 6 41.92 Quite Low
Depression 12 39.72 Quite Low
Renal Failure 2 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between A1Rs and NMDA receptors
Negative_regulation (receptors) of A1R Binding (Interaction) of associated with nmda receptor
1) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.63
As in the hippocampus, A2AR stimulation decreased the affinity of A1Rs for agonists.
Negative_regulation (decreased) of A1R Binding (affinity) of in hippocampus associated with agonist and hippocampus
2) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.56
The researchers first asked whether ischemic preconditioning protects the kidneys of mice strains that lack the genes for individual adenosine receptors (A1AR?
Negative_regulation (lack) of A1AR Binding (individual) of associated with adenocard and sprains and strains
3) Confidence 0.38 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504049 Disease Relevance 1.04 Pain Relevance 0.61
The binding for selective A1R agonists was decreased while the A1R antagonist binding remained unaffected.
Negative_regulation (decreased) of A1R Binding (binding) of associated with antagonist and agonist
4) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.08 Pain Relevance 0.45
The binding for selective A1R agonists was decreased while the A1R antagonist binding remained unaffected.
Neg (unaffected) Negative_regulation (unaffected) of A1R Binding (binding) of associated with antagonist and agonist
5) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.09 Pain Relevance 0.48

General Comments

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